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Proteintech
EXOSC4 Polyclonal Antibody
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Product Details
15937-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
EXOSC4 Fusion Protein Ag7595 (1-245 aa encoded by BC002777)
Conjugate
Form
Liquid
Concentration
0.15 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MAGLELLSD QGYRVDGRRA GELRKIQARM GVFAQADGSA YIEQGNTKAL AVVYGPHEIR GSRARALPDR ALVNCQYSSA TFSTGERKRR PHGDRKSCEM GLQLRQTFEA AILTQLHPRS QIDIYVQVLQ ADGGTYAACV NAATLAVLDA GIPMRDFVCA CSAGFVDGTA LADLSHVEEA AGGPQLALAL LPASGQIALL EMDARLHEDH LERVLEAAAQ AARDVHTLLD RVVRQHVREA SILLGD (1-245 aa encoded by B C002777)
Target Information
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC4 binds to ARE-containing RNAs.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Exosome complex component RRP41; exosome complex exonuclease RRP41; Exosome component 4; exosome component Rrp41; FLJ20591; p12A; Ribosomal RNA-processing protein 41
Gene Aliases: 1110039I09Rik; 1500001N04Rik; EXOSC4; hRrp41p; p12A; RRP41; RRP41A; Rrp41p; SKI6; Ski6p
UniProt ID: (Human) Q9NPD3, (Mouse) Q921I9
Entrez Gene ID: (Human) 54512, (Mouse) 109075, (Rat) 300045
maturation of 5.8S rRNA
nuclear-transcribed mRNA catabolic process
rRNA processing
rRNA catabolic process
positive regulation of cell growth
rRNA 3'-end processing
nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
U4 snRNA 3'-end processing
DNA deamination
defense response to virus
nuclear mRNA surveillance
histone mRNA catabolic process
polyadenylation-dependent snoRNA 3'-end processing
regulation of mRNA stability
exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
RNA phosphodiester bond hydrolysis, exonucleolytic
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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