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EYA1 Polyclonal Antibody

EYA1 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 8

EYA1 Antibody (22658-1-AP) in ICC/IF

Immunofluorescent analysis of HeLa cells using 22658-1-AP (EYA1 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

EYA1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

EYA1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

22658-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 5 publications 5 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

EYA1 Fusion Protein Ag18489 (1-300 aa encoded by BC121799)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.33 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MEMQDLTSP HSRLSGSSES PSGPKLGNSH INSNSMTPNG TEVKTEPMSS SETASTTADG SLNNFSGSAI GSSSFSPRPT HQFSPPQIYP SNRPYPHILP TPSSQTMAAY GQTQFTTGMQ QATAYATYPQ PGQPYGISSY GALWAGIKTE GGLSQSQSPG QTGFLSYGTS FSTPQPGQAP YSYQMQGSSF TTSSGIYTGN NSLTNSSGFN SSQQDYPSYP SFGQGQYAQY YNSSPYPAHY MTSSNTSPTT PSTNATYQLQ EPPSGITSQA VTDPTAEYST IHSPSTPIKD SDSDRLRRGS D (1-300 aa encoded by BC121799)

Target Information

This gene encodes a member of the eyes absent family of proteins. The encoded protein may play a role in the developing kidney, branchial arches, eye, and ear. Mutations of this gene have been associated with branchiootorenal dysplasia syndrome, branchiootic syndrome, and sporadic cases of congenital cataracts and ocular anterior segment anomalies. A similar protein in mice can act as a transcriptional activator. Four transcript variants encoding three distinct isoforms have been identified for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

YTHDF1 phase separation triggers the fate transition of spermatogonial stem cells by activating the IκB-NF-κB-CCND1 axis.

Cell reports

Fang Q,Tian GG,Wang Q,Liu M,He L,Li S,Wu J

Tue Apr 25 00:00:00 UTC 2023

MES23.5 DA Immortalized Neuroblastoma Cells Self-protect Against Early Injury by Overexpressing Glial Cell-derived Neurotrophic Factor via Akt1/Eya1/Six2 Signaling.

Journal of molecular neuroscience : MN

Gao J,Kang XY,Sun S,Li L,Gao DS

Sun Mar 01 00:00:00 UTC 2020

MES23.5 DA Immortalized Neuroblastoma Cells Self-protect Against Early Injury by Overexpressing Glial Cell-derived Neurotrophic Factor via Akt1/Eya1/Six2 Signaling.

Journal of molecular neuroscience : MN

Gao J,Kang XY,Sun S,Li L,Gao DS

Sun Mar 01 00:00:00 UTC 2020

Co-transplantation with adipose-derived cells to improve parathyroid transplantation in a mice model.

Stem cell research & therapy

Cui Q,Zhang D,Kong D,Tang J,Liao X,Yang Q,Ren J,Gong Y,Wu G

Tue May 26 00:00:00 UTC 2020

EYA1 promotes cell migration and tumor metastasis in hepatocellular carcinoma.

American journal of translational research

Kong D,Ma W,Zhang D,Cui Q,Wang K,Tang J,Liu Z,Wu G

Thu Oct 01 00:00:00 UTC 2020

EYA1 promotes cell migration and tumor metastasis in hepatocellular carcinoma.

American journal of translational research

Kong D,Ma W,Zhang D,Cui Q,Wang K,Tang J,Liu Z,Wu G

Thu Oct 01 00:00:00 UTC 2020

SIX1 Activates STAT3 Signaling to Promote the Proliferation of Thyroid Carcinoma via EYA1.

Frontiers in oncology

Kong D,Li A,Liu Y,Cui Q,Wang K,Zhang D,Tang J,Du Y,Liu Z,Wu G,Wu K

Thu Oct 01 00:00:00 UTC 2020

SIX1 Activates STAT3 Signaling to Promote the Proliferation of Thyroid Carcinoma via EYA1.

Frontiers in oncology

Kong D,Li A,Liu Y,Cui Q,Wang K,Zhang D,Tang J,Du Y,Liu Z,Wu G,Wu K

Thu Oct 01 00:00:00 UTC 2020

Dachshund 1 is Differentially Expressed Between Male and Female Breast Cancer: A Matched Case-Control Study of Clinical Characteristics and Prognosis.

Clinical breast cancer

Cui Q,Kong D,Li Z,Ahiable P,Wang K,Wu K,Wu G

Mon Oct 01 00:00:00 UTC 2018

Dachshund 1 is Differentially Expressed Between Male and Female Breast Cancer: A Matched Case-Control Study of Clinical Characteristics and Prognosis.

Clinical breast cancer

Cui Q,Kong D,Li Z,Ahiable P,Wang K,Wu K,Wu G

Mon Oct 01 00:00:00 UTC 2018

Eyes absent gene (EYA1) is a pathogenic driver and a therapeutic target for melanoma.

Oncotarget

Zhou JJ,Huang Y,Zhang X,Cheng Y,Tang L,Ma X

Fri Dec 01 00:00:00 UTC 2017

Eyes absent gene (EYA1) is a pathogenic driver and a therapeutic target for melanoma.

Oncotarget

Zhou JJ,Huang Y,Zhang X,Cheng Y,Tang L,Ma X

Fri Dec 01 00:00:00 UTC 2017

Eyes absent gene (EYA1) is a pathogenic driver and a therapeutic target for melanoma.

Oncotarget

Zhou JJ,Huang Y,Zhang X,Cheng Y,Tang L,Ma X

Fri Dec 01 00:00:00 UTC 2017

Eyes absent gene (EYA1) is a pathogenic driver and a therapeutic target for melanoma.

Oncotarget

Zhou JJ,Huang Y,Zhang X,Cheng Y,Tang L,Ma X

Fri Dec 01 00:00:00 UTC 2017

Bioinformatics

Protein Aliases: Eyes absent; Eyes absent homolog 1; MGC141875; OTTHUMP00000195053; Protein phosphatase EYA1

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Gene Aliases: BOP; BOR; BOS1; EYA1; OFC1

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UniProt ID: (Human) Q99502, (Mouse) P97767

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Entrez Gene ID: (Human) 2138, (Mouse) 14048

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Function(s)

RNA binding protein tyrosine phosphatase activity protein binding metal ion binding phosphoprotein phosphatase activity hydrolase activity

Process(es)

establishment of mitotic spindle orientation metanephros development branching involved in ureteric bud morphogenesis outflow tract morphogenesis double-strand break repair transcription, DNA-templated pattern specification process mesodermal cell fate specification sensory perception of sound anatomical structure morphogenesis response to ionizing radiation striated muscle tissue development histone dephosphorylation protein sumoylation cellular protein localization establishment or maintenance of apical/basal cell polarity peptidyl-tyrosine dephosphorylation aorta morphogenesis outer ear morphogenesis middle ear morphogenesis regulation of neuron differentiation positive regulation of DNA repair positive regulation of Notch signaling pathway positive regulation of transcription from RNA polymerase II promoter neuron fate specification embryonic skeletal system morphogenesis semicircular canal morphogenesis positive regulation of epithelial cell proliferation pharyngeal system development lung epithelial cell differentiation otic vesicle morphogenesis positive regulation of secondary heart field cardioblast proliferation cochlea morphogenesis negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ureteric bud development DNA repair regulation of transcription, DNA-templated protein dephosphorylation cellular response to DNA damage stimulus multicellular organism development organ morphogenesis chromatin modification ear morphogenesis inner ear morphogenesis cell fate commitment positive regulation of transcription, DNA-templated anatomical structure development otic vesicle development

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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EYA1 Polyclonal Antibody

EYA1 Antibody (22658-1-AP) in ICC/IF

Product Details

22658-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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