Proteintech

Elastin Polyclonal Antibody

Elastin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Elastin Antibody (15257-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human lung tissue slide using (Product # 15257-1-AP) (Elastin antibody) at dilution of 1:1,000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

Elastin Antibody in Immunoprecipitation (IP)

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Product Details

15257-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

View 9 publications 9 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Elastin Fusion Protein Ag7179 (307-658 aa encoded by BC065566)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.16 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: GLVPGGPGF GPGVVGVPGA GVPGVGVPGA GIPVVPGAGI PGAAVPGVVS PEAAAKAAAK AAKYGARPGV GVGGIPTYGV GAGGFPGFGV GVGGIPGVAG VPSVGGVPGV GGVPGVGISP EAQAAAAAKA AKYGLVPGVG VAPGVGVAPG VGVAPGVGLA PGVGVAPGVG VAPGVGVAPG IGPGGVAGAA AGLGAGIPGL GVGVGVPGLG VGAGVPGLGV GAGVPGFRAV PGALAAAKAA KYGAAVPGVL GGLGALGGVG IPGGVVGAGP AAAAAAAKAA AKAAQFGLVG AAGLGGLGVG GLGVPGVGGL GGIPPAAAAK AAKYGVAARP GFGLSPIFPG GACLGKACGR KRK (307-658 aa encoded by BC065566)

Target Information

This gene encodes a protein that is one of the two components of elastic fibers. The encoded protein is rich in hydrophobic amino acids such as glycine and proline, which form mobile hydrophobic regions bounded by crosslinks between lysine residues. Deletions and mutations in this gene are associated with supravalvular aortic stenosis (SVAS) and autosomal dominant cutis laxa. Multiple transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Dexamethasone-Induced Arterial Stiffening Is Attenuated by Training due to a Better Balance Between Aortic Collagen and Elastin Levels.

Cardiovascular drugs and therapy

de Paula VF,Tardelli LP,Amaral SL

Thu Aug 01 00:00:00 UTC 2024

Morphologically intact airways in lung fibrosis have an abnormal proteome.

Respiratory research

Herrera JA,Dingle LA,Monetero MA,Venkateswaran RV,Blaikley JF,Granato F,Pearson S,Lawless C,Thornton DJ

Sat Apr 01 00:00:00 UTC 2023

αvβ3 Integrin as a Link between the Development of Fibrosis and Thyroid Hormones in Systemic Sclerosis.

International journal of molecular sciences

Kohon MY,Zaaroor Levy M,Hornik-Lurie T,Shalom A,Berl A,Drucker L,Levy Y,Tartakover Matalon S

Thu May 18 00:00:00 UTC 2023

Fibulin-4 Accelerates Amyloid Formation by Binding with a Keratin 5 Peptide Fragment.

JID innovations : skin science from molecules to population health

Katagiri F,Ueo D,Okubo-Gunge Y,Usui A,Kuwatsuka S,Mine Y,Hamada K,Fujiwara S,Sasaki T,Nomizu M,Utani A

Sun May 01 00:00:00 UTC 2022

Lung damage created by high tidal volume ventilation in rats with monocrotaline-induced pulmonary hypertension.

BMC pulmonary medicine

Kawai M,Zhang E,Kabwe JC,Okada A,Maruyama J,Sawada H,Maruyama K

Sat Mar 05 00:00:00 UTC 2022

Novel insight into the role of clusterin on intraocular pressure regulation by modifying actin polymerization and extracellular matrix remodeling in the trabecular meshwork.

Journal of cellular physiology

Soundararajan A,Wang T,Ghag SA,Kang MH,Pattabiraman PP

Fri Jul 01 00:00:00 UTC 2022

Partial Reconstruction of Uterus Cervix in Rat by Decellularized Human Uterine Cervical Scaffold Combined with Adipose-Derived Stem Cells (ADSCs).

Journal of immunology research

Li Y,Li C,Guo L,Liu X,Hua K,Zhang X

Fri Sep 23 00:00:00 UTC 2022

The Extracellular Matrix Enriched With Exosomes for the Treatment on Pulmonary Fibrosis in Mice.

Frontiers in pharmacology

Yu Y,Liu X,Zhao Z,Xu Z,Qiao Y,Zhou Y,Qiao H,Zhong J,Dai J,Suo G

Fri Dec 24 00:00:00 UTC 2021

Cathepsin K Regulates Intraocular Pressure by Modulating Extracellular Matrix Remodeling and Actin-Bundling in the Trabecular Meshwork Outflow Pathway.

Cells

Soundararajan A,Ghag SA,Vuda SS,Wang T,Pattabiraman PP

Sun Oct 24 00:00:00 UTC 2021

Fibroblasts Derived From Human Adipose Stem Cells Produce More Effective Extracellular Matrix and Migrate Faster Compared to Primary Dermal Fibroblasts.

Aesthetic surgery journal

Gersch RP,Raum JC,Calvert C,Percec I

Wed Jan 01 00:00:00 UTC 2020

Glutaminolysis Promotes Collagen Translation and Stability via α-Ketoglutarate-mediated mTOR Activation and Proline Hydroxylation.

American journal of respiratory cell and molecular biology

Ge J,Cui H,Xie N,Banerjee S,Guo S,Dubey S,Barnes S,Liu G

Thu Mar 01 00:00:00 UTC 2018

Glutaminolysis Promotes Collagen Translation and Stability via α-Ketoglutarate-mediated mTOR Activation and Proline Hydroxylation.

American journal of respiratory cell and molecular biology

Ge J,Cui H,Xie N,Banerjee S,Guo S,Dubey S,Barnes S,Liu G

Thu Mar 01 00:00:00 UTC 2018

miR-29c induction contributes to downregulation of vascular extracellular matrix proteins by glucocorticoids.

American journal of physiology. Cell physiology

Chuang TD,Pearce WJ,Khorram O

Wed Jul 15 00:00:00 UTC 2015

miR-29c induction contributes to downregulation of vascular extracellular matrix proteins by glucocorticoids.

American journal of physiology. Cell physiology

Chuang TD,Pearce WJ,Khorram O

Wed Jul 15 00:00:00 UTC 2015

Long-term effects of maternal undernutrition on offspring carotid artery remodeling: role of miR-29c.

Journal of developmental origins of health and disease

Khorram O,Chuang TD,Pearce WJ

Sat Aug 01 00:00:00 UTC 2015

Long-term effects of maternal undernutrition on offspring carotid artery remodeling: role of miR-29c.

Journal of developmental origins of health and disease

Khorram O,Chuang TD,Pearce WJ

Sat Aug 01 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: Elastin; FLJ38671; FLJ43523; Tropoelastin

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Gene Aliases: ELN; SVAS; WBS; WS

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UniProt ID: (Human) P15502

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Entrez Gene ID: (Human) 2006

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Function(s)

extracellular matrix structural constituent protein binding

Process(es)

respiratory gaseous exchange blood circulation cell proliferation organ morphogenesis extracellular matrix disassembly extracellular matrix organization

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Elastin Polyclonal Antibody

Elastin Antibody (15257-1-AP) in IHC (P)

Product Details

15257-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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