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Endoglin/CD105 Polyclonal Antibody

Endoglin/CD105 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Endoglin/CD105 Antibody (10862-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using 10862-1-AP (Endoglin/CD105 antibody) at dilution of 1:4000 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

Endoglin/CD105 Antibody in Western Blot (WB)

Endoglin/CD105 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

10862-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:1,000

View 9 publications 9 publications

Immunohistochemistry (IHC)

View 8 publications 8 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:2,000-1:8,000

Immunocytochemistry (ICC/IF)

View 4 publications 4 publications

Flow Cytometry (Flow)

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Bovine, Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Endoglin/CD105 Fusion Protein Ag1287 (331-658 aa encoded by BC014271)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: GGRLQTSPA PIQTTPPKDT CSPELLMSLI QTKCADDAMT LVLKKELVAH LKCTITGLTF WDPSCEAEDR GDKFVLRSAY SSCGMQVSAS MISNEAVVNI LSSSSPQRKK VHCLNMDSLS FQLGLYLSPH FLQASNTIEP GQQSFVQVRV SPSVSEFLLQ LDSCHLDLGP EGGTVELIQG RAAKGNCVSL LSPSPEGDPR FSFLLHFYTV PIPKTGTLSC TVALRPKTGS QDQEVHRTVF MRLNIISPDL SGCTSKGLVL PAVLGITFGA FLIGALLTAA LWYIYSHTRS PSKREPVVAV AAPASSESSS TNHSIGSTQS TPCSTSSMA (331-658 aa encoded by BC014271)

Target Information

CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

GATA6 coordinates cross-talk between BMP10 and oxidative stress axis in pulmonary arterial hypertension.

Scientific reports

Toyama T,Kudryashova TV,Ichihara A,Lenna S,Looney A,Shen Y,Jiang L,Teos L,Avolio T,Lin D,Kaplan U,Marden G,Dambal V,Goncharov D,Delisser H,Lafyatis R,Seta F,Goncharova EA,Trojanowska M

Sat Apr 22 00:00:00 UTC 2023

METTL3 promotes SMSCs chondrogenic differentiation by targeting the MMP3, MMP13, and GATA3.

Regenerative therapy

Hu B,Zou X,Yu Y,Jiang Y,Xu H

Wed Mar 01 00:00:00 UTC 2023

Initial and ongoing tobacco smoking elicits vascular damage and distinct inflammatory response linked to neurodegeneration.

Brain, behavior, & immunity - health

Garza AP,Morton L,Pállinger É,Buzás EI,Schreiber S,Schott BH,Dunay IR

Wed Mar 01 00:00:00 UTC 2023

Endoglin aggravates peritoneal fibrosis by regulating the activation of TGF-β/ALK/Smads signaling.

Frontiers in pharmacology

Huang Q,Xiao R,Lu J,Zhang Y,Xu L,Gao J,Sun J,Wang H

Tue Oct 11 00:00:00 UTC 2022

Endoglin aggravates peritoneal fibrosis by regulating the activation of TGF-β/ALK/Smads signaling.

Frontiers in pharmacology

Huang Q,Xiao R,Lu J,Zhang Y,Xu L,Gao J,Sun J,Wang H

Tue Oct 11 00:00:00 UTC 2022

Endoglin aggravates peritoneal fibrosis by regulating the activation of TGF-β/ALK/Smads signaling.

Frontiers in pharmacology

Huang Q,Xiao R,Lu J,Zhang Y,Xu L,Gao J,Sun J,Wang H

Tue Oct 11 00:00:00 UTC 2022

Endoglin aggravates peritoneal fibrosis by regulating the activation of TGF-β/ALK/Smads signaling.

Frontiers in pharmacology

Huang Q,Xiao R,Lu J,Zhang Y,Xu L,Gao J,Sun J,Wang H

Tue Oct 11 00:00:00 UTC 2022

Cancer-associated fibroblasts promote the stemness and progression of renal cell carcinoma via exosomal miR-181d-5p.

Cell death discovery

Ding M,Zhao X,Chen X,Diao W,Kan Y,Cao W,Chen W,Jiang B,Qin H,Gao J,Zhuang J,Zhang Q,Guo H

Tue Nov 01 00:00:00 UTC 2022

The additive effects of photobiomodulation and bioactive glasses on enhancing early angiogenesis.

Biomedical materials (Bristol, England)

Huang L,Gong W,Huang G,Li J,Wu J,Wang Y,Dong Y

Fri May 13 00:00:00 UTC 2022

WISP2/CCN5 Suppresses Vasculogenic Mimicry through Inhibition of YAP/TAZ Signaling in Breast Cancer Cells.

Cancers

Ferrand N,Fert A,Morichon R,Radosevic-Robin N,Zaoui M,Sabbah M

Mon Mar 14 00:00:00 UTC 2022

Response of TGF-β isoforms in epithelial-mesenchymal transition of enamel epithelial cells.

Archives of oral biology

Miyakawa Y,Chiba-Ohkuma R,Karakida T,Yamamoto R,Kobayashi S,Yamakoshi Y,Asada Y

Tue Nov 01 00:00:00 UTC 2022

Appropriate Dose of Dapagliflozin Improves Cardiac Outcomes by Normalizing Mitochondrial Fission and Reducing Cardiomyocyte Apoptosis After Acute Myocardial Infarction.

Drug design, development and therapy

Fan ZG,Xu Y,Chen X,Ji MY,Ma GS

Wed Jul 06 00:00:00 UTC 2022

Endoglin Modulates TGFβR2 Induced VEGF and Proinflammatory Cytokine Axis Mediated Angiogenesis in Prolonged DEHP-Exposed Breast Cancer Cells.

Biomedicines

Jadhao M,Chen CL,Liu W,Deshmukh D,Liao WT,Chen JY,Urade R,Tsai EM,Hsu SK,Wang LF,Chiu CC

Thu Feb 10 00:00:00 UTC 2022

Umbilical artery tissue contains p75 neurotrophin receptor-positive pericyte-like cells that possess neurosphere formation capacity and neurogenic differentiation potential.

Regenerative therapy

Fujii-Tezuka R,Ishige-Wada M,Nagoshi N,Okano H,Mugishima H,Takahashi S,Morioka I,Matsumoto T

Mon Mar 01 00:00:00 UTC 2021

Roquin2 suppresses breast cancer progression by inhibiting tumor angiogenesis via selectively destabilizing proangiogenic factors mRNA.

International journal of biological sciences

Zhou M,Lu W,Li B,Yuan X,Liu M,Han J,Liu X,Li A

Thu Mar 17 00:00:00 UTC 2022

Urolithin a alleviates oxidative stress-induced senescence in nucleus pulposus-derived mesenchymal stem cells through SIRT1/PGC-1α pathway.

World journal of stem cells

Shi PZ,Wang JW,Wang PC,Han B,Lu XH,Ren YX,Feng XM,Cheng XF,Zhang L

Sun Dec 26 00:00:00 UTC 2021

Human umbilical cord mesenchymal stem cells regulate CD54 and CD105 in vascular endothelial cells and suppress inflammation in Kawasaki disease.

Experimental cell research

Chen T,Xu T,Cheng M,Fang H,Shen X,Tang Z,Zhao J

Wed Dec 15 00:00:00 UTC 2021

Human umbilical cord mesenchymal stem cells regulate CD54 and CD105 in vascular endothelial cells and suppress inflammation in Kawasaki disease.

Experimental cell research

Chen T,Xu T,Cheng M,Fang H,Shen X,Tang Z,Zhao J

Wed Dec 15 00:00:00 UTC 2021

Human umbilical cord mesenchymal stem cells regulate CD54 and CD105 in vascular endothelial cells and suppress inflammation in Kawasaki disease.

Experimental cell research

Chen T,Xu T,Cheng M,Fang H,Shen X,Tang Z,Zhao J

Wed Dec 15 00:00:00 UTC 2021

Human umbilical cord mesenchymal stem cells regulate CD54 and CD105 in vascular endothelial cells and suppress inflammation in Kawasaki disease.

Experimental cell research

Chen T,Xu T,Cheng M,Fang H,Shen X,Tang Z,Zhao J

Wed Dec 15 00:00:00 UTC 2021

Inhibition of DNA Methyltransferase by RG108 Promotes Pluripotency-Related Character of Porcine Bone Marrow Mesenchymal Stem Cells.

Cellular reprogramming

Li Q,Zhai Y,Man X,Zhang S,An X

Wed Apr 01 00:00:00 UTC 2020

MMP-14 aggravates onset of severe preeclampsia by mediating soluble endoglin release.

European review for medical and pharmacological sciences

Zhang XH,Zhang HY,Lu S,Jiang LL,Wu J,Yang YL,Zhang SA

Thu Mar 01 00:00:00 UTC 2018

MMP-14 aggravates onset of severe preeclampsia by mediating soluble endoglin release.

European review for medical and pharmacological sciences

Zhang XH,Zhang HY,Lu S,Jiang LL,Wu J,Yang YL,Zhang SA

Thu Mar 01 00:00:00 UTC 2018

MMP-14 aggravates onset of severe preeclampsia by mediating soluble endoglin release.

European review for medical and pharmacological sciences

Zhang XH,Zhang HY,Lu S,Jiang LL,Wu J,Yang YL,Zhang SA

Thu Mar 01 00:00:00 UTC 2018

MMP-14 aggravates onset of severe preeclampsia by mediating soluble endoglin release.

European review for medical and pharmacological sciences

Zhang XH,Zhang HY,Lu S,Jiang LL,Wu J,Yang YL,Zhang SA

Thu Mar 01 00:00:00 UTC 2018

Inhibiting transforming growth factor-β signaling regulates in vitro maintenance and differentiation of bovine bone marrow mesenchymal stem cells.

Journal of experimental zoology. Part B, Molecular and developmental evolution

Zhao XX,An XL,Zhu XC,Jiang Y,Zhai YH,Zhang S,Cai NN,Tang B,Li ZY,Zhang XM

Sat Dec 01 00:00:00 UTC 2018

Inhibiting transforming growth factor-β signaling regulates in vitro maintenance and differentiation of bovine bone marrow mesenchymal stem cells.

Journal of experimental zoology. Part B, Molecular and developmental evolution

Zhao XX,An XL,Zhu XC,Jiang Y,Zhai YH,Zhang S,Cai NN,Tang B,Li ZY,Zhang XM

Sat Dec 01 00:00:00 UTC 2018

Imbalance of angiogenic factors and avascular edematous cystic villi in a trisomy 13 pregnancy: a case report.

Placenta

Kakigano A,Mimura K,Kanagawa T,Nakayama M,Kanayama T,Fujita S,Kinugasa-Taniguchi Y,Endo M,Tomimatsu T,Kimura T

Mon Jul 01 00:00:00 UTC 2013

Imbalance of angiogenic factors and avascular edematous cystic villi in a trisomy 13 pregnancy: a case report.

Placenta

Kakigano A,Mimura K,Kanagawa T,Nakayama M,Kanayama T,Fujita S,Kinugasa-Taniguchi Y,Endo M,Tomimatsu T,Kimura T

Mon Jul 01 00:00:00 UTC 2013

Placental expression of anti-angiogenic proteins in mirror syndrome: a case report.

Placenta

Graham N,Garrod A,Bullen P,Heazell AE

Fri Jun 01 00:00:00 UTC 2012

Placental expression of anti-angiogenic proteins in mirror syndrome: a case report.

Placenta

Graham N,Garrod A,Bullen P,Heazell AE

Fri Jun 01 00:00:00 UTC 2012

Oxidative stress-induced S100B protein from placenta and amnion affects soluble Endoglin release from endothelial cells.

Molecular human reproduction

Tskitishvili E,Sharentuya N,Temma-Asano K,Mimura K,Kinugasa-Taniguchi Y,Kanagawa T,Fukuda H,Kimura T,Tomimatsu T,Shimoya K

Mon Mar 01 00:00:00 UTC 2010

Oxidative stress-induced S100B protein from placenta and amnion affects soluble Endoglin release from endothelial cells.

Molecular human reproduction

Tskitishvili E,Sharentuya N,Temma-Asano K,Mimura K,Kinugasa-Taniguchi Y,Kanagawa T,Fukuda H,Kimura T,Tomimatsu T,Shimoya K

Mon Mar 01 00:00:00 UTC 2010

Bioinformatics

Protein Aliases: CD105; CD105 antigen; Cell surface MJ7/18 antigen; Endoglin; ORW; transmembrane glycoprotein

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Gene Aliases: AI528660; AI662476; CD105; Edg; END; Endo; ENG; HHT1; ORW1; S-endoglin

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UniProt ID: (Human) P17813, (Mouse) Q63961

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Entrez Gene ID: (Human) 2022, (Mouse) 13805, (Rat) 497010

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Function(s)

transmembrane signaling receptor activity transforming growth factor beta receptor, cytoplasmic mediator activity type II transforming growth factor beta receptor binding protein binding galactose binding glycosaminoglycan binding type I transforming growth factor beta receptor binding BMP binding protein homodimerization activity activin binding transforming growth factor beta binding transforming growth factor beta-activated receptor activity

Process(es)

negative regulation of transcription from RNA polymerase II promoter angiogenesis patterning of blood vessels vasculogenesis response to hypoxia positive regulation of protein phosphorylation negative regulation of endothelial cell proliferation heart looping positive regulation of systemic arterial blood pressure cell migration involved in endocardial cushion formation regulation of transcription, DNA-templated protein phosphorylation cell adhesion transmembrane receptor protein serine/threonine kinase signaling pathway transforming growth factor beta receptor signaling pathway heart development positive regulation of gene expression positive regulation of pathway-restricted SMAD protein phosphorylation cell migration regulation of transforming growth factor beta receptor signaling pathway central nervous system vasculogenesis extracellular matrix disassembly negative regulation of cell migration positive regulation of BMP signaling pathway negative regulation of protein autophosphorylation positive regulation of collagen biosynthetic process intracellular signal transduction wound healing positive regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter smooth muscle tissue development artery morphogenesis venous blood vessel morphogenesis cell motility negative regulation of nitric-oxide synthase activity cell chemotaxis negative regulation of pathway-restricted SMAD protein phosphorylation extracellular matrix constituent secretion detection of hypoxia chronological cell aging sprouting angiogenesis endocardial cushion morphogenesis cardiac ventricle morphogenesis cardiac atrium morphogenesis ventricular trabecula myocardium morphogenesis negative regulation of gene expression BMP signaling pathway dorsal aorta morphogenesis endocardial cushion to mesenchymal transition positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation response to corticosteroid response to statin bone development cellular response to mechanical stimulus response to transforming growth factor beta

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Endoglin/CD105 Polyclonal Antibody

Endoglin/CD105 Antibody (10862-1-AP) in IHC (P)

Product Details

10862-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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