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Invitrogen
Endostatin Monoclonal Antibody (1837-46)
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Endostatin Antibody (MA1-40230) in WB
Frontiers in microbiology 2022 -
Figure 4 The expression of endostatin and/or TRAIL by optimized Salmonella and their in vitro cell-killing activities. (A,B) The expression of endostatin (ES, RGD4C-ES, RGD10-ES, and PSMA-ES; 25.2, 28.1, 28.4, and 52.6 kDa) and TRAIL (34.3 kDa) by engineered Salmonella strain D2-asd was detected by western blotting, respectively. The samples tested were prepared from bacterial lysates. (C) Recombinant Salmo... View More
Product Details
MA1-40230
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Bacteria,
Human,
Mouse
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
1837-46
Immunogen
Recombinant human Endostatin
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Protein G
Storage buffer
PBS with 0.1% BSA
Contains
0.02% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2081720
Product Specific Information
MA1-40230 detects Endostatin from human samples.
MA1-40230 has been successfully used in ELISA, flow cytometry, immunohistochemistry (frozen), immunohistochemistry (paraffin), and Western blot applications. For staining of paraffin sections antigen retrieval (microwave irradiation <2x7 minutes> in citrate buffer) is advised.
The MA1-40230 immunogen is human endostatin.
Target Information
Endostatin is able to avoke non-uniform response for proliferation, cell mount and migration of entothelial cells, which different endostatin binding characteristic, leads to the assumption that endostatin effect is strongly dependent from endothelial cell type. Furthermore endostatin inhibits angiogenesis and tumor growth in vivo by inducing apoptosis in endothelial cells. The local delivery of endostatin seems to specifically affect tumor-associated microvessels by reduction of the vessel density, diameter and functionality. Tumor cell migration and invasion was greatly reduced in the endostatin treated animals. Endostatin is non-toxic and does not induce aquired drug resistance and has therefor become a potent new therapy strategy in solid neoplasias. This therapy appears to have a high potential not only for the treatment of gliomas, the most common brain tumors, but also in other tumors. The ability of endostatin to inhibit neoangiogenesis is mediated, at least in part, by Zn^+2 binding and elastase processing. Widespread endostatin expression was found in elactic fibers in vessel walls and in some other basement membrane zones. Endostatin is released by neurons to accumulate in amyloid plaques in Alzheimer's disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: antiangiogenic agent; Collagen alpha-1(XVIII) chain; collagen, type XVIII, alpha 1; endostatin; FLJ27325; FLJ34914; MGC74745; multi-functional protein MFP
Gene Aliases: COL18A1; KNO; KNO1; KS
UniProt ID: (Human) P39060
Entrez Gene ID: (Human) 80781
angiogenesis
endothelial cell morphogenesis
cell adhesion
visual perception
positive regulation of cell proliferation
negative regulation of cell proliferation
organ morphogenesis
extracellular matrix organization
positive regulation of cell migration
collagen catabolic process
response to drug
response to hydrostatic pressure
positive regulation of endothelial cell apoptotic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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