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          • Primary Antibodies ›
          • Endothelin 1 Antibodies

          Proteintech

          Endothelin 1 Polyclonal Antibody

          19 References
          View all (14) Endothelin 1 antibodies

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          Cite Endothelin 1 Polyclonal Antibody

          • Antibody Testing Data (1)
          Endothelin 1 Antibody in Western Blot (WB)
          Group 53 Created with Sketch.
          Endothelin 1 Antibody in Western Blot (WB)
          Group 53 Created with Sketch.

          FIGURE: 1 / 1

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          Endothelin 1 Antibody (12191-1-AP) in WB

          NIH/3T3 cells were subjected to SDS PAGE followed by western blot with 12191-1-AP (Endothelin 1 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          Endothelin 1 Antibody in Western Blot (WB)

          Product Details

          12191-1-AP

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:200-1:1,000
          View 15 publications 15 publications

          Immunohistochemistry (IHC)

          -
          View 2 publications 2 publications

          Immunocytochemistry (ICC/IF)

          Assay-dependent
          View 1 publication 1 publication

          Immunoprecipitation (IP)

          Assay-dependent
          View 1 publication 1 publication
          Product Specifications

          Species Reactivity

          Human, Mouse

          Published species

          Human, Mouse

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          Endothelin 1 Fusion Protein Ag2847 (1-212 aa encoded by BC009720)
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          0.37 mg/mL

          Purification

          Antigen affinity chromatography

          Storage buffer

          PBS, pH 7.3, with 50% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          -20°C

          Shipping conditions

          Wet ice (domestic); Dry ice (international)

          Product Specific Information

          Immunogen sequence: MDYLLMIFS LLFVACQGAP ETAVLGAELS AVGENGGEKP TPSPPWRLRR SKRCSCSSLM DKECVYFCHL DIIWVNTPEH VVPYGLGSPR SKRALENLLP TKATDRENRC QCASQKDKKC WNFCQAGKEL RAEDIMEKDW NNHKKGKDCS KLGKKCIYQQ LVRGRKIRRS SEEHLRQTRS ETMRNSVKSS FHDPKLKGNP SRERYVTHNR AHW (1-212 aa encoded by BC009720)

          Target Information

          The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 also can affect the central nervous system. Two transcript variants encoding different isoforms have been found for this gene.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          Bioinformatics

          Protein Aliases: Big endothelin 1; Big ET; Big ET 1; Big ET1; BigET; Endothelin-1; Et; ET-1; PPET1; preproendothelin; Preproendothelin-1

          View more View less

          Gene Aliases: ARCND3; EDN1; ET-1; ET1; HDLCQ7; PPET1; preproET; QME

          View more View less

          UniProt ID: (Human) P05305, (Mouse) P22387

          View more View less

          Entrez Gene ID: (Human) 1906, (Mouse) 13614

          View more View less

          Function(s)
          cytokine activity hormone activity protein binding endothelin A receptor binding endothelin B receptor binding receptor binding
          Process(es)
          negative regulation of transcription from RNA polymerase II promoter skeletal system development prostaglandin biosynthetic process patterning of blood vessels response to hypoxia in utero embryonic development histamine secretion regulation of systemic arterial blood pressure by endothelin regulation of pH cell surface receptor signaling pathway G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration protein kinase C-activating G-protein coupled receptor signaling pathway cell-cell signaling heart development respiratory gaseous exchange body fluid secretion regulation of blood pressure positive regulation of cell proliferation dorsal/ventral pattern formation positive regulation of heart rate positive regulation of cardiac muscle hypertrophy positive regulation of receptor biosynthetic process neural crest cell development phosphatidylinositol 3-kinase signaling artery smooth muscle contraction vein smooth muscle contraction glucose transport cell growth regulation of vasoconstriction sensory perception of pain calcium-mediated signaling peptide hormone secretion nitric oxide transport positive regulation of cell migration negative regulation of cAMP biosynthetic process phospholipase D-activating G-protein coupled receptor signaling pathway negative regulation of cellular protein metabolic process positive regulation of prostaglandin secretion negative regulation of smooth muscle cell apoptotic process intracellular signal transduction positive regulation of urine volume positive regulation of renal sodium excretion epithelial fluid transport vasoconstriction protein kinase C deactivation middle ear morphogenesis positive regulation of odontogenesis superoxide anion generation rhythmic excitation positive regulation of MAP kinase activity positive regulation of JUN kinase activity positive regulation of cell size positive regulation of mitotic nuclear division positive regulation of transcription from RNA polymerase II promoter positive regulation of smooth muscle contraction positive regulation of hormone secretion negative regulation of hormone secretion inositol phosphate-mediated signaling blood vessel morphogenesis positive regulation of smooth muscle cell proliferation regulation of blood vessel size cartilage development positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway negative regulation of nitric-oxide synthase biosynthetic process membrane depolarization regulation of sensory perception of pain positive regulation of sarcomere organization positive regulation of prostaglandin-endoperoxide synthase activity positive regulation of neutrophil chemotaxis response to ozone multicellular organism aging positive regulation of endothelial cell migration response to activity negative regulation of blood coagulation neutrophil chemotaxis response to lipopolysaccharide response to testosterone response to prostaglandin F response to nicotine cellular response to drug response to muscle stretch response to amino acid response to leptin leukocyte activation positive regulation of nitric oxide biosynthetic process positive regulation of sequence-specific DNA binding transcription factor activity maternal process involved in parturition positive regulation of cell growth involved in cardiac muscle cell development positive regulation of chemokine-mediated signaling pathway cellular response to calcium ion cellular response to interferon-gamma cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to peptide hormone stimulus cellular response to glucocorticoid stimulus cellular response to mineralocorticoid stimulus cellular response to fatty acid cellular response to hypoxia response to dexamethasone cellular response to transforming growth factor beta stimulus response to salt
          It has to be done as per old AB suggested Products section.
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