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Invitrogen
Endothelin 2 Polyclonal Antibody
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Endothelin 2 Antibody (PA3-002) in IHC (P)
Immunohistochemistry analysis of Endothelin-2 was performed on human lung tissue. To expose target proteins, antigen retrieval was performed by microwaving tissues for 20 minutes in 10mM sodium citrate buffer (pH 6.0). Tissue slides were probed with a Endothelin-2 polyclonal antibody (Product # PA3-002) at a dilution of 1:3000, overnight at 4C in a humidified chamber. Tissues were washed, and detection was ... View More
Product Details
PA3-002
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated Cys-S-Abu-SSWLDKE-Abu-VYF-Abu-HLDIIW
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
0.05% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2540481
Product Specific Information
IHC (P) analysis shows positive staining of endothelin-2 in human lung tissue.
Target Information
Endothelins are endothelium-derived vasoconstrictor peptides. Endothelin 2, also known as ET-2, is a protein that in humans is encoded by the EDN2 gene. The secreted peptide (~2kD, 21 amino acids) is produced as a result of endothelin-2 precursor (~20 kD) processing and functions as a ligand for endothelin receptors which upon peptide binding modulates a wide array of cell signaling events. Diseases associated with endothelins include aortic disease and patent ductus arteriosus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: EDN 2; EDN-2; Endothelin-2; ET-2; PP ET-2; PPET2; preproendothelin 2; Preproendothelin-2
Gene Aliases: EDN2; ET-2; ET2; PPET2
UniProt ID: (Human) P20800
Entrez Gene ID: (Human) 1907
prostaglandin biosynthetic process
temperature homeostasis
positive regulation of leukocyte chemotaxis
hormonal regulation of the force of heart contraction
positive regulation of the force of heart contraction by chemical signal
regulation of systemic arterial blood pressure by endothelin
cell surface receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
positive regulation of cell proliferation
positive regulation of heart rate
artery smooth muscle contraction
vein smooth muscle contraction
cytokine-mediated signaling pathway
regulation of vasoconstriction
calcium-mediated signaling
neutrophil chemotaxis
macrophage activation
vasoconstriction
positive regulation of smooth muscle contraction
inositol phosphate-mediated signaling
macrophage chemotaxis
lung alveolus development
positive regulation of prostaglandin-endoperoxide synthase activity
energy homeostasis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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