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Invitrogen
Endothelin 2 Polyclonal Antibody
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Product Details
PA5-113958
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the n terminal region of human EDN2 (aa 1-50).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2884473
Product Specific Information
Immunogen sequence: MVSVPTTWCS VALALLVALH EGKGQAAATL EQPASSSHAQ GTHLRLRRCS
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Predicted homology: Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 93%
Target Information
Endothelins are endothelium-derived vasoconstrictor peptides. Endothelin 2, also known as ET-2, is a protein that in humans is encoded by the EDN2 gene. The secreted peptide (~2kD, 21 amino acids) is produced as a result of endothelin-2 precursor (~20 kD) processing and functions as a ligand for endothelin receptors which upon peptide binding modulates a wide array of cell signaling events. Diseases associated with endothelins include aortic disease and patent ductus arteriosus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EDN 2; EDN-2; Endothelin-2; ET-2; PP ET-2; PPET2; preproendothelin 2; Preproendothelin-2
Gene Aliases: EDN2; ET-2; ET2; PPET2
UniProt ID: (Human) P20800
Entrez Gene ID: (Human) 1907
prostaglandin biosynthetic process
temperature homeostasis
positive regulation of leukocyte chemotaxis
hormonal regulation of the force of heart contraction
positive regulation of the force of heart contraction by chemical signal
regulation of systemic arterial blood pressure by endothelin
cell surface receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
positive regulation of cell proliferation
positive regulation of heart rate
artery smooth muscle contraction
vein smooth muscle contraction
cytokine-mediated signaling pathway
regulation of vasoconstriction
calcium-mediated signaling
neutrophil chemotaxis
macrophage activation
vasoconstriction
positive regulation of smooth muscle contraction
inositol phosphate-mediated signaling
macrophage chemotaxis
lung alveolus development
positive regulation of prostaglandin-endoperoxide synthase activity
energy homeostasis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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