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Invitrogen
Endothelin 3 Monoclonal Antibody (OTI3E10)
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FIGURE: 1 / 3
Endothelin 3 Antibody (MA5-27028) in IHC (P)
Immunohistochemistry was performed on paraffin-embedded human lymphoma tissue. To expose target proteins, heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min. Following antigen retrieval, tissues were probed with a EDN3 monoclonal antibody (Product # MA5-27028) at a dilution of 1:150.
Product Details
MA5-27028
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI3E10
Immunogen
Human recombinant protein fragment corresponding to amino acids 17-238 of EDN3 produced in E.coli
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2723124
Target Information
The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Endothelin-3; ET 3; ET-3; MGC15067; MGC61498; PPET3; Preproendothelin 3; Preproendothelin-3; RP4-614C15.1
Gene Aliases: EDN3; ET-3; ET3; HSCR4; PPET3; WS4B
UniProt ID: (Human) Q03229
Entrez Gene ID: (Human) 1908
neural crest cell migration
positive regulation of leukocyte chemotaxis
regulation of systemic arterial blood pressure by endothelin
cellular calcium ion homeostasis
signal transduction
cell surface receptor signaling pathway
cell-cell signaling
multicellular organism development
blood circulation
positive regulation of cell proliferation
positive regulation of heart rate
regulation of gene expression
cellular magnesium ion homeostasis
artery smooth muscle contraction
vein smooth muscle contraction
regulation of vasoconstriction
peptide hormone secretion
neuron differentiation
melanocyte differentiation
neutrophil chemotaxis
vasoconstriction
positive regulation of MAP kinase activity
positive regulation of cell differentiation
positive regulation of mitotic nuclear division
positive regulation of hormone secretion
inositol phosphate-mediated signaling
regulation of developmental pigmentation
positive regulation of potassium ion transmembrane transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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