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Invitrogen
Endothelin A Receptor Polyclonal Antibody
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Endothelin A Receptor Antibody (PA5-13432) in ICC/IF
Immunocytochemistry analysis of Endothelin A Receptor in HepG2 cells. Samples were incubated in Endothelin A Receptor polyclonal antibody (Product # PA5-13432) followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
Product Details
PA5-13432
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 125-154 amino acids from the central region of human EDNRA
Conjugate
Form
Liquid
Concentration
2 mg/mL
Purification
Size-exclusion - Dialysis, Ammonium sulfate precipitation
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2277673
Product Specific Information
This antibody is predicted to react with mouse and rat based on sequence homology.
Target Information
This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Endothelin A; endothelin receptor subtype A; Endothelin receptor type A; Endothelin-1 receptor; endothelin-1-specific receptor; ET-A; G protein-coupled receptor
Gene Aliases: EDNRA; ET-A; ETA; ETA-R; ETAR; ETRA; hET-AR; MFDA
UniProt ID: (Human) P25101
Entrez Gene ID: (Human) 1909
patterning of blood vessels
response to hypoxia
in utero embryonic development
histamine secretion
glomerular filtration
smooth muscle contraction
signal transduction
G-protein coupled receptor signaling pathway
activation of adenylate cyclase activity
activation of phospholipase C activity
positive regulation of cytosolic calcium ion concentration
protein kinase C-activating G-protein coupled receptor signaling pathway
Rho protein signal transduction
heart development
aging
respiratory gaseous exchange
regulation of blood pressure
cell proliferation
positive regulation of cell proliferation
neural crest cell development
artery smooth muscle contraction
glucose transport
sensory perception of pain
negative regulation of cAMP biosynthetic process
response to lipopolysaccharide
vasoconstriction
positive regulation of odontogenesis
negative regulation of apoptotic process
penile erection
response to morphine
fibroblast proliferation
enteric nervous system development
smooth muscle cell proliferation
regulation of epithelial cell proliferation
positive regulation of inflammatory response
positive regulation of release of sequestered calcium ion into cytosol
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
maternal process involved in parturition
head development
positive regulation of ERK1 and ERK2 cascade
cellular response to mechanical stimulus
endothelin receptor signaling pathway
positive regulation of neutrophil chemotaxis
positive regulation of kidney development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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