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Invitrogen
Endothelin B Receptor Monoclonal Antibody (15C3)
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Endothelin B Receptor Antibody (MA5-49181) in WB
Western blot analysis of EDNRB using EDNRB antibody (Product # MA5-49181). Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 50 µg of sample under reducing conditions. Lane 1: human placenta tissue lysates; Lane 2: human CACO-2 whole cell lysates; Lane 3: human SW620 whole cell lysates; Lane 4: human ... View More
Product Details
MA5-49181
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
15C3
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human EDNRB (406-439aa QSFEEKQSLEEKQSCLKFKANDHGYDNFRSSNKY).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 4mg trehalose
Contains
0.05mg sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_3074839
Product Specific Information
Adding 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
Immunogen sequence is different from the related mouse and rat sequences by one amino acid.
Positive Control - WB: human placenta tissue, human CACO-2 whole cell, human SW620 whole cell, human HepG2 whole cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Target Information
Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AU022549; Endothelin receptor non-selective type; endothelin receptor subtype B1; Endothelin receptor type B; ET-B; Et-b receptor; Et-b-r; ET-RB; Etb receptor; Etb-svr; RP11-318G21.1
Gene Aliases: ABCDS; EDNRB; ET-B; ET-BR; ETB; ETB1; ETBR; ETRB; HSCR; HSCR2; WS4A
UniProt ID: (Human) P24530
Entrez Gene ID: (Human) 1910
negative regulation of transcription from RNA polymerase II promoter
neural crest cell migration
positive regulation of protein phosphorylation
regulation of pH
cell surface receptor signaling pathway
negative regulation of adenylate cyclase activity
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
nervous system development
peripheral nervous system development
posterior midgut development
aging
regulation of blood pressure
positive regulation of cell proliferation
negative regulation of neuron maturation
response to organic cyclic compound
vein smooth muscle contraction
sensory perception of pain
cGMP-mediated signaling
melanocyte differentiation
regulation of fever generation
negative regulation of cellular protein metabolic process
enteric smooth muscle cell differentiation
positive regulation of urine volume
positive regulation of renal sodium excretion
epithelial fluid transport
vasoconstriction
vasodilation
negative regulation of apoptotic process
macrophage chemotaxis
response to pain
enteric nervous system development
regulation of epithelial cell proliferation
regulation of sensory perception of pain
positive regulation of penile erection
cellular response to lipopolysaccharide
endothelin receptor signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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