Alomone Labs, LTD

Endothelin Receptor A Polyclonal Antibody

View all (5) Endothelin A Receptor antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

AER-001-200UL

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100
-
Product Specifications

Species Reactivity

Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

(C)NHNTERSSHKDSMN, corresponding to amino acid residues 413-426 of rat ET-A, Intracellular, C-terminus
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.9 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Target Information

This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Endothelin A; endothelin A receptor; Endothelin receptor type A; Endothelin-1 receptor; ET-A; G-protein coupled receptor 10

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Gene Aliases: Ednra; Endor; ET-A; ET-AR; ETa; Gpcr10; RGD1559432

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UniProt ID: (Rat) P26684, (Mouse) Q61614

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Entrez Gene ID: (Rat) 24326, (Mouse) 13617

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Function(s)
endothelin receptor activity protein tyrosine kinase activity signal transducer activity G-protein coupled receptor activity protein binding
Process(es)
patterning of blood vessels response to hypoxia in utero embryonic development histamine secretion positive regulation of protein phosphorylation glomerular filtration positive regulation of cytosolic calcium ion concentration protein kinase C-activating G-protein coupled receptor signaling pathway Rho protein signal transduction heart development aging respiratory gaseous exchange regulation of blood pressure positive regulation of cell proliferation neural crest cell development response to organic cyclic compound artery smooth muscle contraction glucose transport sensory perception of pain negative regulation of cAMP biosynthetic process response to lipopolysaccharide vasoconstriction positive regulation of odontogenesis negative regulation of apoptotic process penile erection response to morphine fibroblast proliferation enteric nervous system development smooth muscle cell proliferation regulation of epithelial cell proliferation positive regulation of inflammatory response positive regulation of release of sequestered calcium ion into cytosol positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway positive regulation of calcium ion transport maternal process involved in parturition head development positive regulation of ERK1 and ERK2 cascade cellular response to mechanical stimulus endothelin receptor signaling pathway positive regulation of neutrophil chemotaxis positive regulation of kidney development signal transduction G-protein coupled receptor signaling pathway
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