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Invitrogen
EphB4 Polyclonal Antibody
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EphB4 Antibody (PA5-115190) in IHC (P)
Immunohistochemistry analysis of EphB4 in human ovarian cancer and adjacent normal tissues. Samples were treated with formaldehyde and treated with citrate buffer for antigen retrieval, blocked, and incubated (1.5 hours at 22°C) with polyclonal antibody (Product # PA5-115190) at a dilution of 1:100. Secondary staining was applied with HRP conjugated anti-Rabbit.
Product Details
PA5-115190
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human EPHB4(Accession P54760), corresponding to amino acid residues K960-Y987.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2899826
Product Specific Information
Antibody detects endogenous levels of total EPHB4.
Target Information
EPHB4 is a receptor tyrosine kinase that belongs to the ephrin receptor family. Members of the Eph family of kinases play important roles in diverse biological processes including nervous system development, angiogenesis and neural synapsis formation and maturation. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by EphB4 binds to ephrin-B2 and plays an essential role in vascular development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Developmental kinase 2; ephrin receptor EphB4; Ephrin type-B receptor 4; Hepatoma transmembrane kinase; mDK-2; soluble EPHB4 variant 1; soluble EPHB4 variant 2; soluble EPHB4 variant 3; Tyrosine kinase MYK-1; tyrosine-protein kinase receptor HTK; Tyrosine-protein kinase TYRO11
Gene Aliases: AI042935; EPHB4; HTK; MDK2; MYK1; TYRO11
UniProt ID: (Human) P54760, (Mouse) P54761
Entrez Gene ID: (Human) 2050, (Mouse) 13846
angiogenesis
cell migration involved in sprouting angiogenesis
heart morphogenesis
cell adhesion
peptidyl-tyrosine phosphorylation
protein autophosphorylation
ephrin receptor signaling pathway
protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
multicellular organism development
phosphorylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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