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This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation.
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Protein Aliases: Epididymal secretory protein 4; MGC57529; RE4; WAP domain-containing protein HE4; WAP four-disulfide core domain protein 2
Gene Aliases: 1600023A02Rik; HE4; re4; WAP5; Wfdc2
UniProt ID: (Rat) Q8CHN3, (Mouse) Q9DAU7
Entrez Gene ID: (Rat) 286888, (Mouse) 67701
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