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Invitrogen
Epiregulin Polyclonal Antibody
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Epiregulin Antibody (PA5-47057) in WB
Western blot analysis of Epiregulin in P19 mouse embryonal carcinoma cell line. Samples were incubated in Epiregulin polyclonal antibody (Product # PA5-47057) using a dilution of 1 µg/mL followed by a HRP-conjugated Anti-Goat IgG secondary antibody. A specific band was detected for Proepiregulin at approximately 28 kDa (as indicated). This experiment was conducted under reducing conditions.
Product Details
PA5-47057
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived recombinant mouse Epiregulin Val56-Leu101
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2607378
Product Specific Information
In direct ELISAs, approximately 40% cross-reactivity with recombinant human Epiregulin is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
Target Information
Epiregulin is an EGF-related growth factor that binds specifically to EGFR (ErbB1) and ErbB4, but not ErbB2 or ErbB3. It is expressed mainly in the placenta and peripheral blood leukocytes, as well as in certain carcinomas of the bladder, lung, kidney and colon. Epiregulin stimulates the proliferation of keratinocytes, hepatocytes, fibroblasts and vascular smooth muscle cells. It also inhibits the growth of several tumor-derived epithelial cell lines. Human Epiregulin is initially synthesized as a glycosylated 19.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce a 6.0 kDa mature secreted sequence.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Proepiregulin
Gene Aliases: EPR; Ereg
UniProt ID: (Mouse) Q61521
Entrez Gene ID: (Mouse) 13874
activation of MAPK activity
angiogenesis
ovarian cumulus expansion
oocyte maturation
positive regulation of cytokine production
female meiotic division
epidermal growth factor receptor signaling pathway
cell-cell signaling
multicellular organism development
positive regulation of cell proliferation
negative regulation of cell proliferation
mRNA transcription
anatomical structure morphogenesis
organ morphogenesis
cytokine-mediated signaling pathway
cell differentiation
ovulation
positive regulation of cytokine biosynthetic process
positive regulation of phosphorylation
luteinizing hormone signaling pathway
keratinocyte proliferation
positive regulation of innate immune response
positive regulation of interleukin-6 biosynthetic process
positive regulation of DNA replication
positive regulation of epidermal growth factor-activated receptor activity
positive regulation of mitotic nuclear division
positive regulation of protein kinase activity
negative regulation of transcription, DNA-templated
positive regulation of fibroblast proliferation
primary follicle stage
positive regulation of smooth muscle cell proliferation
negative regulation of smooth muscle cell differentiation
positive regulation of cell division
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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