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Invitrogen
Epstein Barr Virus Early Antigen Monoclonal Antibody (1108-1)
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Product Details
MA1-35751
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Virus
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1108-1
Immunogen
EBV early antigens.
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
purified
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_1074255
Product Specific Information
1108-1 Recognizes a 55-50 kDa polypeptide associated with the early antigen of Epstein-Barr virus (EBV). p55 Has beenshown to be a phosphoprotein and p55-50 has strong DNA-binding activity preferentially to single-stranded DNA. Epstein-Barr virus is the causitive agent of infectious mononucleosis and is associated with two human neoplasms, Burkitt's lymphoma and nasopharyngeal carcinoma. Several EBV-related antigens associated with early or late functions of the viral genome have been identified. The early antigen may be virally or chemically induced in EBV infected cells and is the first detectable marker of EBV infection in human cells.
Target Information
Epstein-Barr virus (EBV) is a human herpes virus, which is associated with conditions such as Hodgkin's disease and Burkitt's Lymphoma and is the causative agent in mononucleosis in adolescents. EBV latently infects B lymphocytes. Infected B cells express EBV nuclear antigens and latent proteins LMP1, LMP2A and LMP2B. LMP2A forms aggregates in the plasma membranes of B lymphocytes, where it functions as a negative regulator of the Src and Syk protein tyrosine kinases. Studies show that LMP2A blocks B-cell receptor (BCR) signal transduction in EBV immortalized B cells in vitro and may play an important role in maintaining a latent EBV infection within the peripheral blood B cells of infected individuals.EBNA-1 is the only viral protein consistently expressed in all malignancies associated with EBV.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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