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Proteintech
Ezrin Polyclonal Antibody, CoraLite® Plus 488
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Product Details
CL488-26056
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Purification
Antigen affinity chromatography
Storage buffer
PBS with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: VYEPVSYHVQ ESLQDEGAEP TGYSAELSSE GIRDDRNEEK RITEAEKNER VQR
Target Information
The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cytovillin; cytovillin 2; DKFZp762H157; epididymis secretory protein Li 105; EZRI; Ezrin; FLJ26216; MGC1584; p81; villin 2; villin 2 (ezrin); Villin-2
Gene Aliases: AW146364; CVIL; CVL; EZR; HEL-S-105; p81; R75297; VIL2
UniProt ID: (Human) P15311, (Mouse) P26040
Entrez Gene ID: (Human) 7430, (Mouse) 22350
actin binding
protein binding
microtubule binding
protein domain specific binding
protein kinase A catalytic subunit binding
protein kinase A regulatory subunit binding
S100 protein binding
poly(A) RNA binding
cell adhesion molecule binding
actin filament binding
ATPase binding
cadherin binding involved in cell-cell adhesion
cytoskeletal protein binding
protein complex binding
intestinal D-glucose absorption
sphingosine-1-phosphate signaling pathway
regulation of cell shape
positive regulation of gene expression
microvillus assembly
actin cytoskeleton reorganization
receptor internalization
regulation of microvillus length
establishment or maintenance of apical/basal cell polarity
positive regulation of multicellular organism growth
filopodium assembly
phosphatidylinositol-mediated signaling
positive regulation of protein secretion
actin filament bundle assembly
establishment of endothelial barrier
positive regulation of establishment of protein localization to plasma membrane
regulation of organelle assembly
terminal web assembly
positive regulation of protein localization to early endosome
positive regulation of cellular protein catabolic process
positive regulation of early endosome to late endosome transport
negative regulation of transcription from RNA polymerase II promoter
cytoskeletal anchoring at plasma membrane
leukocyte cell-cell adhesion
axon guidance
regulation of cell size
protein kinase A signaling
gland morphogenesis
membrane to membrane docking
astral microtubule organization
regulation of actin cytoskeleton organization
cellular protein complex localization
cortical microtubule organization
establishment of epithelial cell apical/basal polarity
negative regulation of T cell receptor signaling pathway
establishment of centrosome localization
negative regulation of ERK1 and ERK2 cascade
cellular response to cAMP
protein localization to cell cortex
establishment of protein localization to plasma membrane
negative regulation of interleukin-2 secretion
regulation of NIK/NF-kappaB signaling
negative regulation of p38MAPK cascade
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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