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Proteintech
F7 Polyclonal Antibody
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Product Details
23058-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
F7 Fusion Protein Ag19324 (120-466 aa encoded by BC130468)
Conjugate
Form
Liquid
Concentration
0.41 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: SCKDQLQSY ICFCLPAFEG RNCETHKDDQ LICVNENGGC EQYCSDHTGT KRSCRCHEGY SLLADGVSCT PTVEYPCGKI PILEKRNASK PQGRIVGGKV CPKGECPWQV LLLVNGAQLC GGTLINTIWV VSAAHCFDKI KNWRNLIAVL GEHDLSEHDG DEQSRRVAQV IIPSTYVPGT TNHDIALLRL HQPVVLTDHV VPLCLPERTF SERTLAFVRF SLVSGWGQLL DRGATALELM VLNVPRLMTQ DCLQQSRKVG DSPNITEYMF CAGYSDGSKD SCKGDSGGPH ATHYRGTWYL TGIVSWGQGC ATVGHFGVYT RVSQYIEWLQ KLMRSEPRPG VLLRAPFP (120-466 aa encoded by BC130468)
Target Information
Coagulation factor VII is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in F7 production can cause coagulopathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Coagulation factor VII; coagulation factor VII (serum prothrombin conversion accelerator); eptacog alfa; Factor 7; Factor7; FVII coagulation protein; Proconvertin; Serum prothrombin conversion accelerator; SPCA
Gene Aliases: AI132620; Cf7; F7; FVII; SPCA
UniProt ID: (Mouse) P70375, (Human) P08709
Entrez Gene ID: (Mouse) 14068, (Human) 2155
positive regulation of leukocyte chemotaxis
signal peptide processing
ER to Golgi vesicle-mediated transport
blood coagulation
blood coagulation, extrinsic pathway
circadian rhythm
positive regulation of platelet-derived growth factor receptor signaling pathway
response to organic cyclic compound
protein processing
peptidyl-glutamic acid carboxylation
positive regulation of blood coagulation
positive regulation of cell migration
organ regeneration
response to vitamin K
response to estrogen
positive regulation of positive chemotaxis
positive regulation of protein kinase B signaling
response to growth hormone
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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