Proteintech

FABP5 Polyclonal Antibody

FABP5 Antibody in Immunocytochemistry (ICC/IF)

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FABP5 Antibody (12348-1-AP) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol) fixed U2OS cells using 12348-1-AP (FABP5 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

FABP5 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Product Image Gallery

Product Details

12348-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 25 publications 25 publications

Immunohistochemistry (IHC)

View 8 publications 8 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:50-1:500

View 7 publications 7 publications

Flow Cytometry (Flow)

Assay-dependent

Immunoprecipitation (IP)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

FABP5 Fusion Protein Ag3005 (1-135 aa encoded by BC019385)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.43 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MATVQQLEG RWRLVDSKGF DEYMKELGVG IALRKMGAMA KPDCIITCDG KNLTIKTEST LKTTQFSCTL GEKFEETTAD GRKTQTVCNF TDGALVQHQE WDGKESTITR KLKDGKLVVE CVMNNVTCTR IYEKVE (1-135 aa encoded by B C019385)

Target Information

FABP5 (fatty acid binding protein 5 (psoriasis-associated)) is a proteinthat in humans is encoded by theFABP5 gene, also known as PAFABP, EFABP, E-FABP, KFABP, PA-FABP, Epidermal-type fatty acid-binding protein, Fatty acid-binding protein 5, Psoriasis-associated fatty acid-binding protein homolog. It is a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. The PAFABP cDNA encodes a 135-amino acid protein with molecular weight 15,164. This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated inpsoriasistissue. It is though that FABPs roles include fatty acid uptake, transport, and metabolism. Kaczocha et al. (2009) identifiedFABP5and FABP7 as cytosolic proteins that transport AEA from the plasma membrane to subcellular fatty acid amide hydrolase, where it is hydrolyzed and inactivated. FABP3 did not show this specific transport function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

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Wu Z,Hu G,Zhang Y,Ao Z

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Effects of Fatty Acids on Proliferation of Cultured Wild-type and FABP5-KO Thymic Epithelial Cells.

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Adachi Y

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Effects of Fatty Acids on Proliferation of Cultured Wild-type and FABP5-KO Thymic Epithelial Cells.

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Tue Sep 13 00:00:00 UTC 2022

Adenosine-rich extract of Ganoderma lucidum: A safe and effective lipid-lowering substance.

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Fatty acid-binding protein 5 aggravates pulmonary artery fibrosis in pulmonary hypertension secondary to left heart disease via activating wnt/β-catenin pathway.

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Lipid-lowering activity of metformin-soluble soybean polysaccharide nanoparticles.

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He H,Liu M,He R,Zhao W

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Soybean soluble polysaccharide prevents obesity in high-fat diet-induced rats via lipid metabolism regulation.

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Thu Dec 01 00:00:00 UTC 2022

Fatty acid binding protein 5 promotes the proliferation, migration, and invasion of hepatocellular carcinoma cells by degradation of Krüppel-like factor 9 mediated by miR-889-5p via cAMP-response element binding protein.

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Differentially expressed proteins identified by TMT proteomics analysis in children with verrucous epidermal naevi.

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Tue Jun 01 00:00:00 UTC 2021

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Wed Sep 01 00:00:00 UTC 2021

Oxidative stress-induced FABP5 S-glutathionylation protects against acute lung injury by suppressing inflammation in macrophages.

Nature communications

Guo Y,Liu Y,Zhao S,Xu W,Li Y,Zhao P,Wang D,Cheng H,Ke Y,Zhang X

Tue Dec 07 00:00:00 UTC 2021

Oxidative stress-induced FABP5 S-glutathionylation protects against acute lung injury by suppressing inflammation in macrophages.

Nature communications

Guo Y,Liu Y,Zhao S,Xu W,Li Y,Zhao P,Wang D,Cheng H,Ke Y,Zhang X

Tue Dec 07 00:00:00 UTC 2021

Oxidative stress-induced FABP5 S-glutathionylation protects against acute lung injury by suppressing inflammation in macrophages.

Nature communications

Guo Y,Liu Y,Zhao S,Xu W,Li Y,Zhao P,Wang D,Cheng H,Ke Y,Zhang X

Tue Dec 07 00:00:00 UTC 2021

Oxidative stress-induced FABP5 S-glutathionylation protects against acute lung injury by suppressing inflammation in macrophages.

Nature communications

Guo Y,Liu Y,Zhao S,Xu W,Li Y,Zhao P,Wang D,Cheng H,Ke Y,Zhang X

Tue Dec 07 00:00:00 UTC 2021

Heparin-Binding Protein 17/Fibroblast Growth Factor-Binding Protein-1 Knockout Inhibits Proliferation and Induces Differentiation of Squamous Cell Carcinoma Cells.

Cancers

Shintani T,Higaki M,Okamoto T

Sat May 29 00:00:00 UTC 2021

MMP-12 siRNA improves the homeostasis of the small intestine and metabolic dysfunction in high-fat diet feeding-induced obese mice.

Biomaterials

Song M,Zhang S,Tao Z,Li J,Shi Y,Xiong Y,Zhang W,Liu C,Chen S

Mon Nov 01 00:00:00 UTC 2021

Deregulating the CYP2C19/Epoxy-Eicosatrienoic Acid-Associated FABP4/FABP5 Signaling Network as a Therapeutic Approach for Metastatic Triple-Negative Breast Cancer.

Cancers

Apaya MK,Hsiao PW,Yang YC,Shyur LF

Mon Jan 13 00:00:00 UTC 2020

Deregulating the CYP2C19/Epoxy-Eicosatrienoic Acid-Associated FABP4/FABP5 Signaling Network as a Therapeutic Approach for Metastatic Triple-Negative Breast Cancer.

Cancers

Apaya MK,Hsiao PW,Yang YC,Shyur LF

Mon Jan 13 00:00:00 UTC 2020

Deregulating the CYP2C19/Epoxy-Eicosatrienoic Acid-Associated FABP4/FABP5 Signaling Network as a Therapeutic Approach for Metastatic Triple-Negative Breast Cancer.

Cancers

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Cancers

Apaya MK,Hsiao PW,Yang YC,Shyur LF

Mon Jan 13 00:00:00 UTC 2020

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Molecular biology of the cell

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Lin28 enhances de novo fatty acid synthesis to promote cancer progression via SREBP-1.

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Zhang S,Liu H,Li H,Wu M,Yu Y,Li F,Cheng X

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Differential CRABP-II and FABP5 expression patterns and implications for medulloblastoma retinoic acid sensitivity.

RSC advances

Zhang S,Liu H,Li H,Wu M,Yu Y,Li F,Cheng X

Wed Apr 11 00:00:00 UTC 2018

Differential CRABP-II and FABP5 expression patterns and implications for medulloblastoma retinoic acid sensitivity.

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Wed Apr 11 00:00:00 UTC 2018

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Li YT,Tian XT,Wu ML,Zheng X,Kong QY,Cheng XX,Zhu GW,Liu J,Li H

Thu Mar 29 00:00:00 UTC 2018

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Li YT,Tian XT,Wu ML,Zheng X,Kong QY,Cheng XX,Zhu GW,Liu J,Li H

Thu Mar 29 00:00:00 UTC 2018

Resveratrol Suppresses the Growth and Enhances Retinoic Acid Sensitivity of Anaplastic Thyroid Cancer Cells.

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Li YT,Tian XT,Wu ML,Zheng X,Kong QY,Cheng XX,Zhu GW,Liu J,Li H

Thu Mar 29 00:00:00 UTC 2018

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International journal of molecular sciences

Li YT,Tian XT,Wu ML,Zheng X,Kong QY,Cheng XX,Zhu GW,Liu J,Li H

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Tue Jan 10 00:00:00 UTC 2017

Dual Inhibition of PI3K/Akt and mTOR by the Dietary Antioxidant, Delphinidin, Ameliorates Psoriatic Features In Vitro and in an Imiquimod-Induced Psoriasis-Like Disease in Mice.

Antioxidants & redox signaling

Chamcheu JC,Adhami VM,Esnault S,Sechi M,Siddiqui IA,Satyshur KA,Syed DN,Dodwad SM,Chaves-Rodriquez MI,Longley BJ,Wood GS,Mukhtar H

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Molecular & cellular proteomics : MCP

Rong Z,Fan T,Li H,Li J,Wang K,Wang X,Dong J,Chen J,Wang F,Wang J,Wang A

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Differential Proteomic Analysis of Gender-dependent Hepatic Tumorigenesis in Hras12V Transgenic Mice.

Molecular & cellular proteomics : MCP

Rong Z,Fan T,Li H,Li J,Wang K,Wang X,Dong J,Chen J,Wang F,Wang J,Wang A

Tue Aug 01 00:00:00 UTC 2017

CRABP-II- and FABP5-independent responsiveness of human glioblastoma cells to all-trans retinoic acid.

Oncotarget

Xia SL,Wu ML,Li H,Wang JH,Chen NN,Chen XY,Kong QY,Sun Z,Liu J

Fri Mar 20 00:00:00 UTC 2015

CRABP-II- and FABP5-independent responsiveness of human glioblastoma cells to all-trans retinoic acid.

Oncotarget

Xia SL,Wu ML,Li H,Wang JH,Chen NN,Chen XY,Kong QY,Sun Z,Liu J

Fri Mar 20 00:00:00 UTC 2015

CRABP-II- and FABP5-independent responsiveness of human glioblastoma cells to all-trans retinoic acid.

Oncotarget

Xia SL,Wu ML,Li H,Wang JH,Chen NN,Chen XY,Kong QY,Sun Z,Liu J

Fri Mar 20 00:00:00 UTC 2015

CRABP-II- and FABP5-independent responsiveness of human glioblastoma cells to all-trans retinoic acid.

Oncotarget

Xia SL,Wu ML,Li H,Wang JH,Chen NN,Chen XY,Kong QY,Sun Z,Liu J

Fri Mar 20 00:00:00 UTC 2015

E-FABP induces differentiation in normal human keratinocytes and modulates the differentiation process in psoriatic keratinocytes in vitro.

Experimental dermatology

Dallaglio K,Marconi A,Truzzi F,Lotti R,Palazzo E,Petrachi T,Saltari A,Coppini M,Pincelli C

Mon Apr 01 00:00:00 UTC 2013

E-FABP induces differentiation in normal human keratinocytes and modulates the differentiation process in psoriatic keratinocytes in vitro.

Experimental dermatology

Dallaglio K,Marconi A,Truzzi F,Lotti R,Palazzo E,Petrachi T,Saltari A,Coppini M,Pincelli C

Mon Apr 01 00:00:00 UTC 2013

Allergen-induced dermatitis causes alterations in cutaneous retinoid-mediated signaling in mice.

PloS one

Gericke J,Ittensohn J,Mihály J,Dubrac S,Rühl R

Tue Apr 08 00:00:00 UTC 2014

Allergen-induced dermatitis causes alterations in cutaneous retinoid-mediated signaling in mice.

PloS one

Gericke J,Ittensohn J,Mihály J,Dubrac S,Rühl R

Tue Apr 08 00:00:00 UTC 2014

Allergen-induced dermatitis causes alterations in cutaneous retinoid-mediated signaling in mice.

PloS one

Gericke J,Ittensohn J,Mihály J,Dubrac S,Rühl R

Tue Apr 08 00:00:00 UTC 2014

Allergen-induced dermatitis causes alterations in cutaneous retinoid-mediated signaling in mice.

PloS one

Gericke J,Ittensohn J,Mihály J,Dubrac S,Rühl R

Tue Apr 08 00:00:00 UTC 2014

CRABP-II- and FABP5-independent all-trans retinoic acid resistance in COLO 16 human cutaneous squamous cancer cells.

Experimental dermatology

Chen NN,Li Y,Wu ML,Liu ZL,Fu YS,Kong QY,Chen XY,Li H,Liu J

Sun Jan 01 00:00:00 UTC 2012

CRABP-II- and FABP5-independent all-trans retinoic acid resistance in COLO 16 human cutaneous squamous cancer cells.

Experimental dermatology

Chen NN,Li Y,Wu ML,Liu ZL,Fu YS,Kong QY,Chen XY,Li H,Liu J

Sun Jan 01 00:00:00 UTC 2012

CRABP-II- and FABP5-independent all-trans retinoic acid resistance in COLO 16 human cutaneous squamous cancer cells.

Experimental dermatology

Chen NN,Li Y,Wu ML,Liu ZL,Fu YS,Kong QY,Chen XY,Li H,Liu J

Sun Jan 01 00:00:00 UTC 2012

CRABP-II- and FABP5-independent all-trans retinoic acid resistance in COLO 16 human cutaneous squamous cancer cells.

Experimental dermatology

Chen NN,Li Y,Wu ML,Liu ZL,Fu YS,Kong QY,Chen XY,Li H,Liu J

Sun Jan 01 00:00:00 UTC 2012

Identification of potential therapeutic targets in human head & neck squamous cell carcinoma.

Head & neck oncology

Han J,Kioi M,Chu WS,Kasperbauer JL,Strome SE,Puri RK

Tue Jul 14 00:00:00 UTC 2009

Identification of potential therapeutic targets in human head & neck squamous cell carcinoma.

Head & neck oncology

Han J,Kioi M,Chu WS,Kasperbauer JL,Strome SE,Puri RK

Tue Jul 14 00:00:00 UTC 2009

Bioinformatics

Protein Aliases: C-FABP; Cutaneous fatty acid-binding protein; DA11; E-FABP; E-FABPPAFABP; Epidermal-type fatty acid-binding protein; epithelial fatty acid-binding protein; fatty acid binding protein 5 (psoriasis-associated); Fatty acid-binding protein 5; Fatty acid-binding protein, epidermal; Keratinocyte lipid-binding protein; PA-FABP; PA-FABPepidermal; Psoriasis-associated fatty acid-binding protein homolog

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Gene Aliases: C-FABP; DA11; E-FABP; EFABP; FABP5; Fabpe; KFABP; Klbp; Mal1; PA-FABP; PAFABP

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UniProt ID: (Human) Q01469, (Rat) P55053, (Mouse) Q05816

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Entrez Gene ID: (Human) 2171, (Rat) 140868, (Mouse) 16592

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Function(s)

transporter activity fatty acid binding protein binding lipid binding

Process(es)

glucose metabolic process lipid metabolic process phosphatidylcholine biosynthetic process transport response to wounding glucose transport epidermis development triglyceride catabolic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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FABP5 Polyclonal Antibody

FABP5 Antibody (12348-1-AP) in ICC/IF

Product Details

12348-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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