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NeoBiotechnologies
FABP5 (Marker of Metastatic Potential in Colorectal Cancer) Recombinant Rabbit Monoclonal Antibody (FABP5/6353R)
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Product Details
2171-RBM3-P1
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
FABP5/6353R
Immunogen
Recombinant human full-length FABP5 protein
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
Protein A/G
Storage buffer
PBS with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Antibody is stable for 24 months.
Positive Control: MOLT-4, HeLa or HEK-293 cells. Keratinocytes; highly expressed in psoriatic skin. Cellular Localization: Nuclear. Cytoplasmic.
Specificity Comments: This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in psoriasis tissue. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs may play roles in fatty acid uptake, transport, and metabolism. Polymorphisms in this gene are associated with type 2 diabetes. The human genome contains many pseudogenes similar to this locus. FABP5 is also associated with poor survival in triple-negative breast cancer. Additionally, FABP5 gene is upregulated in colorectal cancer cells compared to normal colon cells in a manner that correlates with disease stage and that FABP5 significantly promotes colorectal cancer cell growth and metastatic potential.
Target Information
FABP5 (fatty acid binding protein 5 (psoriasis-associated)) is a proteinthat in humans is encoded by theFABP5 gene, also known as PAFABP, EFABP, E-FABP, KFABP, PA-FABP, Epidermal-type fatty acid-binding protein, Fatty acid-binding protein 5, Psoriasis-associated fatty acid-binding protein homolog. It is a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. The PAFABP cDNA encodes a 135-amino acid protein with molecular weight 15,164. This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated inpsoriasistissue. It is though that FABPs roles include fatty acid uptake, transport, and metabolism. Kaczocha et al. (2009) identifiedFABP5and FABP7 as cytosolic proteins that transport AEA from the plasma membrane to subcellular fatty acid amide hydrolase, where it is hydrolyzed and inactivated. FABP3 did not show this specific transport function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: E-FABP; E-FABPPAFABP; Epidermal-type fatty acid-binding protein; fatty acid binding protein 5 (psoriasis-associated); Fatty acid-binding protein 5; Fatty acid-binding protein, epidermal; PA-FABP; PA-FABPepidermal; Psoriasis-associated fatty acid-binding protein homolog
Gene Aliases: E-FABP; EFABP; FABP5; KFABP; PA-FABP; PAFABP
UniProt ID: (Human) Q01469
Entrez Gene ID: (Human) 2171
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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