Invitrogen

FADD Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-78260

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000
-

Immunocytochemistry (ICC/IF)

5 µg/ml
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein encompassing a sequence within the center region of Human FADD. The exact sequence is proprietary.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.58 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 20% glycerol

Contains

0.025% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2735773

Product Specific Information

Positive Control: HeLa, HeLa (30 µM Cisplatin treatment for 24 hr)

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Fas (TNFRSF6)-associated via death domain; FAS-associated death domain protein; FAS-associating death domain-containing protein; Fas-associating protein with death domain; Growth-inhibiting gene 3 protein; Mediator of receptor induced toxicity; mediator of receptor-induced toxicity; MGC8528

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Gene Aliases: FADD; GIG3; MORT1

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UniProt ID: (Human) Q13158

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Entrez Gene ID: (Human) 8772

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Function(s)
protease binding death receptor binding tumor necrosis factor receptor binding protein binding protein complex binding tumor necrosis factor receptor superfamily binding death effector domain binding identical protein binding caspase binding
Process(es)
positive regulation of T cell mediated cytotoxicity positive regulation of adaptive immune response apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process cell surface receptor signaling pathway extrinsic apoptotic signaling pathway via death domain receptors positive regulation of interferon-gamma production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production T cell differentiation in thymus TRIF-dependent toll-like receptor signaling pathway TRAIL-activated apoptotic signaling pathway positive regulation of activated T cell proliferation T cell homeostasis positive regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response positive regulation of macrophage differentiation positive regulation of proteolysis positive regulation of transcription from RNA polymerase II promoter lymph node development spleen development thymus development protein heterooligomerization defense response to virus positive regulation of type I interferon-mediated signaling pathway negative regulation of necroptotic process negative regulation of activation-induced cell death of T cells cellular response to mechanical stimulus death-inducing signaling complex assembly motor neuron apoptotic process apoptotic signaling pathway extrinsic apoptotic signaling pathway extrinsic apoptotic signaling pathway in absence of ligand activation of cysteine-type endopeptidase activity activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway necroptotic signaling pathway regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation positive regulation of extrinsic apoptotic signaling pathway
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