Invitrogen

FADD Recombinant Rabbit Monoclonal Antibody (10L6M0)

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Datasheet
Protocols
Questions & Answers

Product Details

MA5-38032

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

10L6M0

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-205 of mouse FADD (NP_0343051)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.85 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2897950

Product Specific Information

Positive Samples: NIH/3T3, Mouse brain, Mouse thymus

Immunogen sequence: MDPFLVLLHS LSGSLSGNDL MELKFLCRER VSKRKLERVQ SGLDLFTVLL EQNDLERGHT GLLRELLASL RRHDLLQRLD DFEAGTATAA PPGEADLQVA FDIVCDNVGR DWKRLARELK VSEAKMDGIE EKYPRSLSER VRESLKVWKN AEKKNASVAG LVKALRTCRL NLVADLVEEA QESVSKSENM SPVLRDSTVS SSETP

Target Information

The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Fas (TNFRSF6)-associated via death domain; FAS-associated death domain protein; FAS-associating death domain-containing protein; Fas-associating protein with death domain; Growth-inhibiting gene 3 protein; Mediator of receptor induced toxicity; mediator of receptor-induced toxicity; MGC8528; protein FADD

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Gene Aliases: FADD; GIG3; MORT1; Mort1/FADD

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UniProt ID: (Human) Q13158, (Mouse) Q3TC37

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Entrez Gene ID: (Human) 8772, (Mouse) 14082, (Rat) 266610

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Function(s)
protease binding death receptor binding tumor necrosis factor receptor binding protein binding protein complex binding tumor necrosis factor receptor superfamily binding death effector domain binding identical protein binding caspase binding
Process(es)
positive regulation of T cell mediated cytotoxicity immune system process positive regulation of adaptive immune response apoptotic process signal transduction T cell differentiation positive regulation of interferon-gamma production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production T cell differentiation in thymus TRAIL-activated apoptotic signaling pathway positive regulation of activated T cell proliferation regulation of apoptotic process T cell homeostasis positive regulation of apoptotic process innate immune response positive regulation of macrophage differentiation positive regulation of proteolysis positive regulation of transcription from RNA polymerase II promoter lymph node development spleen development thymus development cardiac muscle tissue development protein heterooligomerization defense response to virus positive regulation of type I interferon-mediated signaling pathway negative regulation of necroptotic process negative regulation of activation-induced cell death of T cells motor neuron apoptotic process apoptotic signaling pathway extrinsic apoptotic signaling pathway extrinsic apoptotic signaling pathway in absence of ligand activation of cysteine-type endopeptidase activity necroptotic signaling pathway positive regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation positive regulation of extrinsic apoptotic signaling pathway positive regulation of I-kappaB kinase/NF-kappaB signaling cellular response to mechanical stimulus activation of cysteine-type endopeptidase activity involved in apoptotic process cell surface receptor signaling pathway extrinsic apoptotic signaling pathway via death domain receptors TRIF-dependent toll-like receptor signaling pathway death-inducing signaling complex assembly activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
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