Abnova

FADD Monoclonal Antibody (3C2)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

H00008772-M06

Applications
Tested Dilution
Publications

Western Blot (WB)

1-5 µg/mL
-

ELISA (ELISA)

0.03 ng/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1, lambda

Class

Monoclonal

Type

Antibody

Clone

3C2

Immunogen

FADD (AAH00334, 109 a.a. approximately 208 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: GKDWRRLARQ LKVSDTKIDS IEDRYPRNLT ERVRESLRIW KNTEKENATV AHLVGALRSC QMNLVADLVQ EVQQARDLQN RSGAMSPMSW NSDASTSEAS

Target Information

The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Fas (TNFRSF6)-associated via death domain; FAS-associated death domain protein; FAS-associating death domain-containing protein; Fas-associating protein with death domain; Growth-inhibiting gene 3 protein; Mediator of receptor induced toxicity; mediator of receptor-induced toxicity; MGC8528

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Gene Aliases: FADD; GIG3; MORT1

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UniProt ID: (Human) Q13158

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Entrez Gene ID: (Human) 8772

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Function(s)
protease binding death receptor binding tumor necrosis factor receptor binding protein binding protein complex binding tumor necrosis factor receptor superfamily binding death effector domain binding identical protein binding caspase binding
Process(es)
positive regulation of T cell mediated cytotoxicity positive regulation of adaptive immune response apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process cell surface receptor signaling pathway extrinsic apoptotic signaling pathway via death domain receptors positive regulation of interferon-gamma production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production T cell differentiation in thymus TRIF-dependent toll-like receptor signaling pathway TRAIL-activated apoptotic signaling pathway positive regulation of activated T cell proliferation T cell homeostasis positive regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response positive regulation of macrophage differentiation positive regulation of proteolysis positive regulation of transcription from RNA polymerase II promoter lymph node development spleen development thymus development protein heterooligomerization defense response to virus positive regulation of type I interferon-mediated signaling pathway negative regulation of necroptotic process negative regulation of activation-induced cell death of T cells cellular response to mechanical stimulus death-inducing signaling complex assembly motor neuron apoptotic process apoptotic signaling pathway extrinsic apoptotic signaling pathway extrinsic apoptotic signaling pathway in absence of ligand activation of cysteine-type endopeptidase activity activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway necroptotic signaling pathway regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation positive regulation of extrinsic apoptotic signaling pathway
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