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Invitrogen
FADS1 Recombinant Rabbit Monoclonal Antibody (JE55-63)
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FIGURE: 1 / 10
FADS1 Antibody (MA5-42500) in ICC/IF
Immunocytochemistry-Immunofluorescence analysis of of FADS1 in PANC-1 cells (green). Formalin fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 10 minutes at room temperature and blocked with 1% Blocker BSA for 15 minutes at room temperature. Cells were probed with FADS1 Recombinant Monoclonal Antibody (Product # MA5-42500) at a dilution of 1:50 for 1 hour at room temperature, washed with PBS. Alexa Fluor 488 Goat anti-Rabbit IgG was used as the secondary antibody at 1:1,000 dilution. The nuclear counter stain is DAPI (blue)... View More
Product Details
MA5-42500
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
JE55-63
Immunogen
Synthetic peptide within N-terminal Human FADS1
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 40% glycerol, 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2911641
Product Specific Information
Positive Control: Rat liver tissue lysate, mouse liver tissue lysate, mouse brain tissue lysate, rat lung tissue lysate, Hela cell lysate, A549 cell lysate, Hela, PANC-1, human liver carcinoma tissue, human thyroid tissue, human colon carcinoma tissue, human breast carcinoma tissue, human stomach carcinoma tissue, human small intestine tissue, A549.
Subcellular Location: Mitochondrion, Endoplasmic reticulum membrane.
Target Information
The protein encoded by this gene is a member of the fatty acid desaturase gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members FADS1 and FADS2 at 11q12-q13. 1; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Acyl-CoA (8-3)-desaturase; BC269730_2; D5D; delta(5) desaturase; Delta(5) fatty acid desaturase; delta-5 desaturase; delta-5 fatty acid desaturase; Fatty acid desaturase 1; FLJ38956; FLJ90273; linoleoyl-CoA desaturase (delta-6-desaturase)-like 1
Gene Aliases: 0710001O03Rik; A930006B21Rik; AI317215; D5D; DSD; FADS1; FADS6; FADSD5; LLCDL1; TU12
UniProt ID: (Human) O60427, (Mouse) Q920L1, (Rat) Q920R3
Entrez Gene ID: (Human) 3992, (Mouse) 76267, (Rat) 84575
C-5 sterol desaturase activity
oxidoreductase activity
omega-6 fatty acid desaturase activity
linoleoyl-CoA desaturase activity
acyl-CoA desaturase activity
oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
iron ion binding
heme binding
regulation of transcription, DNA-templated
unsaturated fatty acid biosynthetic process
cell-cell signaling
phospholipid biosynthetic process
cellular response to starvation
alpha-linolenic acid metabolic process
linoleic acid metabolic process
regulation of cell differentiation
icosanoid biosynthetic process
oxidation-reduction process
lipid metabolic process
fatty acid metabolic process
fatty acid biosynthetic process
transport
arachidonic acid metabolic process
long-chain fatty acid biosynthetic process
aging
response to nutrient
response to sucrose
response to organic substance
response to organic cyclic compound
response to insulin
response to vitamin A
response to isolation stress
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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