Proteintech

FAK Polyclonal Antibody

FAK Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 17

FAK Antibody (12636-1-AP) in ICC/IF

Immunofluorescent analysis of (-20°C Methanol) fixed A549 cells using FAK antibody (Product # 12636-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L), CoraLite®594 Beta Actin antibody (CL594-66009, Clone: 2D4H5, red).

FAK Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FAK Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

12636-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 61 publications 61 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

View 5 publications 5 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Miscellaneous PubMed (MISC)

View 3 publications 3 publications

Not applicable (N/A)

View 4 publications 4 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

FAK Fusion Protein Ag3331 (381-678 aa encoded by BC028733)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.53 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: ITAMAGSIY PGQASLLDQT DSWNHRPQEI AMWQPNVEDS TVLDLRGIGQ VLPTHLMEER LIRQQQEMEE DQRWLEKEER FLKPDVRLSR GSIDREDGSL QGPIGNQHIY QPVGKPDPAA PPKKPPRPGA PGHLGSLASL SSPADSYNEG VKLKPQEISP PPTANLDRSN DKVYENVTGL VKAVIEMSSK IQPAPPEEYV PMVKEVGLAL RTLLATVDET IPLLPASTHR EIEMAQKLLN SDLGELINKM KLAQQYVMTS LQQEYKKQML TAAHALAVDA KNLLDVIDQA RLKMLGQTR (381-678 aa encoded by BC028733)

Target Information

Focal Adhesion Kinase (FAK) is a 125 kDa non-receptor protein tyrosine kinase that acts as a substrate for Src and is a key element of integrin signaling. FAK plays an important role in cell spreading, differentiation, migration, cell death, and acceleration of the G1 to S phase transition of the cell cycle. FAK has a central catalytic domain and a C-terminal tail that localizes it to focal adhesions, which are sites where cells attach to the extracellular matrix via surface integrin receptors. Increased FAK tyrosine phosphorylation occurs upon integrin engagement with fibronectin. Adhesion of murine NIH3T3 fibroblasts to fibronectin promotes association of the Grb2 adapter protein and c-Src PTK with FAK in vivo, and also results in activation of the ERK2 MAP kinase. In v-Src-transformed NIH3T3, the association of v-Src, Grb2, and Sos with FAK is independent of cell adhesion to fibronectin. In vitro the Grb2 SH2 domain binds directly to tyrosine-phosphorylated FAK, and the binding site has been identified as Tyr925 by site directed mutagenesis. Several transcript variants encoding different isoforms have been found for the FAK gene, but the full-length natures of only three of them have been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Experimental cell research

Liu C,Liu Y,Xu XX,Wu H,Xie HG,Chen L,Lu T,Yang L,Guo X,Sun GW,Wang W,Ma XJ,He X

Thu Jan 01 00:00:00 UTC 2015

DLC-1 induces mitochondrial apoptosis and epithelial mesenchymal transition arrest in nasopharyngeal carcinoma by targeting EGFR/Akt/NF-κB pathway.

Medical oncology (Northwood, London, England)

Huang W,Liu J,Feng X,Chen H,Zeng L,Huang G,Liu W,Wang L,Jia W,Chen J,Ren C

Wed Apr 01 00:00:00 UTC 2015

DLC-1 induces mitochondrial apoptosis and epithelial mesenchymal transition arrest in nasopharyngeal carcinoma by targeting EGFR/Akt/NF-κB pathway.

Medical oncology (Northwood, London, England)

Huang W,Liu J,Feng X,Chen H,Zeng L,Huang G,Liu W,Wang L,Jia W,Chen J,Ren C

Wed Apr 01 00:00:00 UTC 2015

Arene ruthenium(ii) complex, a potent inhibitor against proliferation, migration and invasion of breast cancer cells, reduces stress fibers, focal adhesions and invadopodia.

Metallomics : integrated biometal science

Wu Q,He J,Mei W,Zhang Z,Wu X,Sun F

Mon Dec 01 00:00:00 UTC 2014

Arene ruthenium(ii) complex, a potent inhibitor against proliferation, migration and invasion of breast cancer cells, reduces stress fibers, focal adhesions and invadopodia.

Metallomics : integrated biometal science

Wu Q,He J,Mei W,Zhang Z,Wu X,Sun F

Mon Dec 01 00:00:00 UTC 2014

A monoclonal antibody targeting neuropilin-1 inhibits adhesion of MCF7 breast cancer cells to fibronectin by suppressing the FAK/p130cas signaling pathway.

Anti-cancer drugs

Zeng F,Luo F,Lv S,Zhang H,Cao C,Chen X,Wang S,Li Z,Wang X,Dou X,Dai Y,He M,Zhang Y,Lv H,Yan J,Chen Y

Tue Jul 01 00:00:00 UTC 2014

A monoclonal antibody targeting neuropilin-1 inhibits adhesion of MCF7 breast cancer cells to fibronectin by suppressing the FAK/p130cas signaling pathway.

Anti-cancer drugs

Zeng F,Luo F,Lv S,Zhang H,Cao C,Chen X,Wang S,Li Z,Wang X,Dou X,Dai Y,He M,Zhang Y,Lv H,Yan J,Chen Y

Tue Jul 01 00:00:00 UTC 2014

Effects of stable knockdown of Aurora kinase A on proliferation, migration, chromosomal instability, and expression of focal adhesion kinase and matrix metalloproteinase-2 in HEp-2 cells.

Molecular and cellular biochemistry

Zhang H,Chen X,Liu B,Zhou L

Tue Nov 01 00:00:00 UTC 2011

Effects of stable knockdown of Aurora kinase A on proliferation, migration, chromosomal instability, and expression of focal adhesion kinase and matrix metalloproteinase-2 in HEp-2 cells.

Molecular and cellular biochemistry

Zhang H,Chen X,Liu B,Zhou L

Tue Nov 01 00:00:00 UTC 2011

Effects of stable knockdown of Aurora kinase A on proliferation, migration, chromosomal instability, and expression of focal adhesion kinase and matrix metalloproteinase-2 in HEp-2 cells.

Molecular and cellular biochemistry

Zhang H,Chen X,Liu B,Zhou L

Tue Nov 01 00:00:00 UTC 2011

Effects of stable knockdown of Aurora kinase A on proliferation, migration, chromosomal instability, and expression of focal adhesion kinase and matrix metalloproteinase-2 in HEp-2 cells.

Molecular and cellular biochemistry

Zhang H,Chen X,Liu B,Zhou L

Tue Nov 01 00:00:00 UTC 2011

Gain of miR-151 on chromosome 8q24.3 facilitates tumour cell migration and spreading through downregulating RhoGDIA.

Nature cell biology

Ding J,Huang S,Wu S,Zhao Y,Liang L,Yan M,Ge C,Yao J,Chen T,Wan D,Wang H,Gu J,Yao M,Li J,Tu H,He X

Thu Apr 01 00:00:00 UTC 2010

Gain of miR-151 on chromosome 8q24.3 facilitates tumour cell migration and spreading through downregulating RhoGDIA.

Nature cell biology

Ding J,Huang S,Wu S,Zhao Y,Liang L,Yan M,Ge C,Yao J,Chen T,Wan D,Wang H,Gu J,Yao M,Li J,Tu H,He X

Thu Apr 01 00:00:00 UTC 2010

Focal adhesion kinase antisense oligodeoxynucleotides inhibit human pulmonary artery smooth muscle cells proliferation and promote human pulmonary artery smooth muscle cells apoptosis.

Chinese medical journal

Lin CL,Zhang ZX,Xu YJ,Ni W,Chen SX

Wed Jan 05 00:00:00 UTC 2005

Focal adhesion kinase antisense oligodeoxynucleotides inhibit human pulmonary artery smooth muscle cells proliferation and promote human pulmonary artery smooth muscle cells apoptosis.

Chinese medical journal

Lin CL,Zhang ZX,Xu YJ,Ni W,Chen SX

Wed Jan 05 00:00:00 UTC 2005

Bioinformatics

Protein Aliases: EC 2.7.10.2; FADK 1; FAK-related non-kinase polypeptide; Focal adhesion kinase 1; focal adhesion kinase isoform FAK-Del33; Focal adhesion kinase-related nonkinase; focal ashension kinase 1; FRNK; p125FAK; pp125 PTK2; pp125FAK; PPP1R71; Protein phosphatase 1 regulatory subunit 71; protein phosphatase 1, regulatory subunit 71; Protein-tyrosine kinase 2; PTK2 protein tyrosine kinase 2

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Gene Aliases: FADK; FAK; FAK1; FRNK; Kiaa4203; mKIAA4203; p125FAK; pp125FAK; PPP1R71; PTK2

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UniProt ID: (Human) Q05397, (Mouse) P34152, (Rat) O35346

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Entrez Gene ID: (Human) 5747, (Mouse) 14083, (Rat) 25614

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Function(s)

actin binding protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity signal transducer activity Ras guanyl-nucleotide exchange factor activity receptor binding protein binding ATP binding JUN kinase binding protein kinase binding SH2 domain binding nucleotide binding integrin binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups protein complex binding identical protein binding phosphatidylinositol 3-kinase binding

Process(es)

Performance Guarantee

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FAK Polyclonal Antibody

FAK Antibody (12636-1-AP) in ICC/IF

Product Details

12636-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Miscellaneous PubMed (MISC)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

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