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Product Details
PA5-56755
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human FAM83B. Recombinant protein control fragment (Product #RP-94944).
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2641465
Product Specific Information
Immunogen sequence: NHSVALNQTT NGHTESNNYI YKTLGVNKQT ENLKNQQTEN LLKRRSFPLF DNSKANLDPG NSKHYVYSTL TRNRVRQPEK PKEDLLKSSK SM
Highest antigen sequence identity to the following orthologs: Mouse - 72%, Rat - 71%.
Target Information
The FAM83B gene, also known as Family With Sequence Similarity 83 Member B, is located on chromosome 6q22.1. This gene encodes a protein that functions as an oncogene and plays a crucial role in the development and progression of various human cancers including breast, prostate, and endometrial cancers. FAM83B exerts its oncogenic effects primarily through the PI3K/AKT/mTOR signaling pathway, promoting cell proliferation, migration, and invasion while inhibiting apoptosis. Additionally, FAM83B has been found to regulate mitochondrial metabolism and maintain cellular energy homeostasis. Knockdown studies of FAM83B in cancer cell lines have demonstrated significant reductions in tumor growth and metastatic potential, highlighting its potential as a therapeutic target. The gene includes multiple exons and undergoes alternative splicing, contributing to its functional diversity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: family with sequence similarity 83, member B; Protein FAM83B
Gene Aliases: C6orf143; FAM83B
UniProt ID: (Human) Q5T0W9
Entrez Gene ID: (Human) 222584
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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