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Product Details
BS-6758R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human FAM89B/MMTV-R, amino acids 41-150.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C184L ORF2 protein; C184M protein; family with sequence similarity 89, member B; Leucine repeat adapter protein 25; leucine repeat adaptor protein 25; Mammary tumor virus receptor 2; mammary tumor virus receptor homolog 1; MMTV receptor; protein FAM89B
Gene Aliases: 1110021A21Rik; C184m; FAM89B; LRAP25; MMTV; MTVR; MTVR1; Mtvr2
UniProt ID: (Human) Q8N5H3, (Rat) Q566R4, (Mouse) Q9QUI1
Entrez Gene ID: (Human) 23625, (Rat) 309170, (Mouse) 17826
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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