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Invitrogen
FANCD2 Monoclonal Antibody (FI-17)
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FIGURE: 1 / 17
FANCD2 Antibody (MA1-16570) in WB
Western blot was performed using Anti-FANCD2 Monoclonal Antibody (FI-17) (Product # MA1-16570) and a 166 kDa band corresponding to FANCD2 was observed across cell lines tested and monoubiquitinated upon Hydroxyurea treatment in HeLa cells. Modified whole cell extracts (1% SDS) (40 µg lysate) of MCF7 (Lane 1), HeLa treated with Hydroxyurea (2 mmol for 24 Hours) (Lane 2) and HeLa (Lane 3) were electrophoresed using NuPAGE™ 4-12% Bis-Tris Protein Gel (Product # NP0322BOX). Resolved proteins were then transferred onto a nitrocellulose membrane... View More
Product Details
MA1-16570
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
FI-17
Immunogen
FANCD2 fusion protein
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
ascites
Contains
0.1% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_568533
Product Specific Information
By Western blot, this antibody recognizes a band at ~155 and ~162 kDa (post-translationally modified form).
Suggested positive control: Hela whole cell extract.
Target Information
FANCD2 (Fanconi anemia group D2 protein) is required for maintenance of chromosomal stability. It promotes accurate and efficient pairing of homologs during meiosis. FANCD2 is involved in the repair of DNA double-stranded breaks, both by homologous recombination and single-stranded annealing. It is required for the targeting/stabilization of BLM to non-centromeric abnormal structures induced by replicative stress. FANCD2 promotes BRCA2/FANCD1 loading onto damaged chromatin. Defects in the FANCD2 gene result in Fanconi anemia complementation group D2. This disorder affects all bone marrow elements resulting in anemia, leukopenia, and thrombopenia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DKFZp762A223; FACD2; Fanconi anemia group D2 protein; Fanconi anemia, complementation group D2; FLJ23826; Protein FACD2
Gene Aliases: FA-D2; FA4; FACD; FAD; FAD2; FANCD; FANCD2
UniProt ID: (Human) Q9BXW9
Entrez Gene ID: (Human) 2177
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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