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Bioss
FAP1 Polyclonal Antibody
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Product Details
BS-5760R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human FAP1/PTPN13, amino acids 801-900.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp686J1497; FAP-1; Fas-associated protein-tyrosine phosphatase 1; hPTPE1; protein Tyr phosphatase; Protein tyrosine phosphatase DPZPTP; Protein tyrosine phosphatase PTP-BL; protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase); Protein-tyrosine phosphatase 1E; Protein-tyrosine phosphatase PTPL1; Protein-tyrosine phosphatase RIP; PTP-BAS; PTP-E1; PTP36; tyrosine phosphatase; Tyrosine-protein phosphatase non-receptor type 13
Gene Aliases: AI324989; FAP-1; hPTP1E; PNP1; ptp; PTP-BAS; PTP-BL; Ptp14; PTP1E; PTPL1; PTPLE; PTPN13; Ptpri; RIP
UniProt ID: (Human) Q12923, (Mouse) Q64512
Entrez Gene ID: (Human) 5783, (Mouse) 19249, (Rat) 498331
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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