Invitrogen

FAS Monoclonal Antibody (GH-9)

View all (71) FAS (CD95) antibodies

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Datasheet
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Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA1-7624

Applications
Tested Dilution
Publications

Western Blot (WB)

2-5 µg/mL
-

ELISA (ELISA)

1:500
-

Immunoprecipitation (IP)

2-5 µg/10^6 cells
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

GH-9

Immunogen

Purified recombinant FAS protein.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.0 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.2

Contains

0.01% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Dry ice

RRID

AB_1073508

Product Specific Information

MA1-7624 detects FAS from human, rat and mouse samples.

MA1-7624 has been successfully used in ELISA, Western blot and immunoprecipitation procedures.

The MA1-7624 immunogen is a purified recombinant FAS protein.

Target Information

CD95, also known as Fas or APO-1, is a 46 kDa transmembrane glycoprotein that functions as a cell death receptor in the tumor necrosis factor receptor (TNFR) superfamily. It is expressed by a wide range of hematopoietic and non-hematopoietic cells, including monocytes, neutrophils, lymphocytes, and fibroblasts. CD95 also exists in a soluble form weighing approximately 26 kDa. The interaction of CD95 with its ligand, FasL, induces apoptosis, playing a crucial role in peripheral tolerance and anti-viral immune responses. Upon stimulation, CD95 leads to the aggregation of its intracellular Fas-associated death domains (FADD), formation of the death-inducing signaling complex (DISC), and activation of caspases. This cascade results in apoptosis. CD95 is also involved in activating NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and transduces proliferative signals in normal diploid fibroblasts and T cells. There are at least eight alternatively spliced transcript variants encoding seven distinct isoforms of CD95. Isoforms lacking the transmembrane domain may negatively regulate apoptosis mediated by the full-length isoform. The Fas/Fas ligand system is implicated in several human diseases, including AIDS, hepatitis, and cancer, highlighting its importance in immune regulation and disease pathology.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Apo-1 antigen; APO-1 cell surface antigen; Apo-1 Fas; Apo1 antigen; apoptosis antigen 1; apoptosis signaling receptor FAS; Apoptosis-mediating surface antigen FAS; CD95; CD95 antigen; Fas (TNF receptor superfamily member); Fas (TNF receptor superfamily, member 6); Fas AMA; Fas antigen; Fas antigen (ATP1); Fas receptor; FASLG receptor; lymphoproliferation; OTTHUMP00000020045; OTTHUMP00000020046; OTTHUMP00000020051; OTTHUMP00000059646; TNF receptor superfamily member 6; Tumor necrosis factor receptor superfamily member 6; Tumor necrosis factor receptor superfamily, member 6

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Gene Aliases: AI196731; ALPS1A; APO-1; APO1; APT1; CD95; FAS; FAS1; FASTM; lpr; TNFR6; TNFRSF6

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UniProt ID: (Human) Q14293, (Rat) Q63199, (Mouse) P25446

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Entrez Gene ID: (Human) 355, (Rat) 246097, (Mouse) 14102

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Function(s)
protease binding signal transducer activity receptor activity tumor necrosis factor-activated receptor activity protein binding kinase binding protein complex binding identical protein binding transmembrane signaling receptor activity
Process(es)
ovarian follicle atresia response to hypoxia immunoglobulin production renal system process apoptotic process activation-induced cell death of T cells inflammatory cell apoptotic process obsolete transformed cell apoptotic process immune response spermatogenesis aging circadian rhythm extrinsic apoptotic signaling pathway via death domain receptors response to toxic substance response to inorganic substance gene expression regulation of gene expression positive regulation of cell death B cell mediated immunity telencephalon development dendrite regeneration positive regulation of protein homooligomerization response to lipopolysaccharide tumor necrosis factor-mediated signaling pathway response to cytokine regulation of cell proliferation response to drug ovulation cycle regulation of apoptotic process chordate embryonic development T cell homeostasis positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process response to peptide hormone response to estrogen negative thymic T cell selection regulation of lymphocyte differentiation regulation of myeloid cell differentiation response to cycloheximide spleen development negative regulation of B cell activation protein homooligomerization response to glucocorticoid neuron apoptotic process maternal process involved in female pregnancy cellular response to hydrogen peroxide response to growth factor cellular response to phenylalanine cellular response to mechanical stimulus cellular response to cobalt ion cellular response to lithium ion cellular response to glucose stimulus cellular response to cytokine stimulus cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to estrogen stimulus cellular response to organic cyclic compound cellular response to hyperoxia cellular response to hypoxia cellular response to hydrostatic pressure motor neuron apoptotic process apoptotic signaling pathway extrinsic apoptotic signaling pathway extrinsic apoptotic signaling pathway in absence of ligand hepatocyte apoptotic process liver regeneration necroptotic signaling pathway response to fluoride positive regulation of extrinsic apoptotic signaling pathway in absence of ligand signal transduction positive regulation of release of cytochrome c from mitochondria protein complex assembly activation of cysteine-type endopeptidase activity involved in apoptotic process inflammatory response brain development regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of MAPK cascade positive regulation of lymphocyte apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
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