Invitrogen

FAS (CD95) Polyclonal Antibody

View all (106) FAS (CD95) antibodies

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Datasheet
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Datasheet
Protocols
Questions & Answers

Product Details

PA5-115214

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human FAS(Accession P25445), corresponding to amino acid residues I295-V335.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2899850

Product Specific Information

Antibody detects endogenous levels of total FAS.

Target Information

FAS (Fas, CD95, APO-1) is a 46 kDa transmembrane glycoprotein that functions as a cell death receptor of the TNFR (tumor necrosis factor receptor) superfamily. FAS also exists in a soluble form that weight approximately 26kDa. Stimulation of FAS results in aggregation of its intracellular FAS-associated death domains (FADD), formation of the death-inducing signaling complex (DISC) and activation of caspases. The auto-proteolytic processing of the caspases in the complex trigger a downstream cascade that leads to apoptosis. FAS has been shown to activate NF-kappaB, MAPK3/ERK1, MAPK8/JNK, and is involved in transducing the proliferating signals in normal diploid fibroblast and T cells. At least eight alternatively spliced transcript variants encoding seven distinct isoforms have been described. The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full-length isoform. The Fas/Fas ligand system has been shown to play a role in a number of human diseases such as AIDS, hepatitis and cancer. It is also assumed that induction of apoptosis through FAS ligand pathway is predominantly involved in anti-viral immune responses.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Apo-1 antigen; APO-1 cell surface antigen; Apo-1 Fas; Apo1 antigen; apoptosis antigen 1; apoptosis signaling receptor FAS; Apoptosis-mediating surface antigen FAS; CD95; CD95 antigen; Fas (TNF receptor superfamily member); Fas (TNF receptor superfamily, member 6); Fas AMA; Fas antigen; Fas antigen (ATP1); Fas receptor; FASLG receptor; lymphoproliferation; OTTHUMP00000020045; OTTHUMP00000020046; OTTHUMP00000020051; OTTHUMP00000059646; TNF receptor superfamily member 6; Tumor necrosis factor receptor superfamily member 6; Tumor necrosis factor receptor superfamily, member 6

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Gene Aliases: AI196731; ALPS1A; APO-1; APO1; APT1; CD95; FAS; FAS1; FASTM; lpr; TNFR6; TNFRSF6

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UniProt ID: (Human) Q14293, (Rat) Q63199, (Mouse) P25446

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Entrez Gene ID: (Human) 355, (Rat) 246097, (Mouse) 14102

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Function(s)
protease binding signal transducer activity receptor activity tumor necrosis factor-activated receptor activity protein binding kinase binding protein complex binding identical protein binding transmembrane signaling receptor activity
Process(es)
ovarian follicle atresia response to hypoxia immunoglobulin production renal system process apoptotic process activation-induced cell death of T cells inflammatory cell apoptotic process obsolete transformed cell apoptotic process immune response spermatogenesis aging circadian rhythm extrinsic apoptotic signaling pathway via death domain receptors response to toxic substance response to inorganic substance gene expression regulation of gene expression positive regulation of cell death B cell mediated immunity telencephalon development dendrite regeneration positive regulation of protein homooligomerization response to lipopolysaccharide tumor necrosis factor-mediated signaling pathway response to cytokine regulation of cell proliferation response to drug ovulation cycle regulation of apoptotic process chordate embryonic development T cell homeostasis positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process response to peptide hormone response to estrogen negative thymic T cell selection regulation of lymphocyte differentiation regulation of myeloid cell differentiation response to cycloheximide spleen development negative regulation of B cell activation protein homooligomerization response to glucocorticoid neuron apoptotic process maternal process involved in female pregnancy cellular response to hydrogen peroxide response to growth factor cellular response to phenylalanine cellular response to mechanical stimulus cellular response to cobalt ion cellular response to lithium ion cellular response to glucose stimulus cellular response to cytokine stimulus cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to estrogen stimulus cellular response to organic cyclic compound cellular response to hyperoxia cellular response to hypoxia cellular response to hydrostatic pressure motor neuron apoptotic process apoptotic signaling pathway extrinsic apoptotic signaling pathway extrinsic apoptotic signaling pathway in absence of ligand hepatocyte apoptotic process liver regeneration necroptotic signaling pathway response to fluoride positive regulation of extrinsic apoptotic signaling pathway in absence of ligand signal transduction positive regulation of release of cytochrome c from mitochondria protein complex assembly activation of cysteine-type endopeptidase activity involved in apoptotic process inflammatory response brain development regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of MAPK cascade positive regulation of lymphocyte apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
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