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Bethyl Laboratories
FAT4 Polyclonal Antibody
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Product Details
A305-883A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A region between residue 4931 and 4981 of human Protocadherin Fat 4.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
phosphate, tris citrate
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Predicted reactivity by homology: Mouse.
Target Information
FAT1, FAT2, FAT3 and FAT4 are human homologs of Drosophila Fat, which is involved in tumor suppression and planar cell polarity (PCP). FAT4 undergo the first proteolytic cleavage by Furin and are predicted to undergo the second cleavage by secretase to release intracellular domain (ICD). FAT4 directly interacts with MPDZ/MUPP1 to recruit membrane associated guanylate kinase MPP5/PALS1. FAT4 is involved in the maintenance of PCP and inhibition of cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cadherin family member 14; cadherin-related family member 11; FAT tumor suppressor homolog 4; Fat-like cadherin protein FAT-J; hFat4; Protocadherin Fat 4; putative protein product of Nbla00548
Gene Aliases: CDHF14; CDHR11; FAT-J; FAT4; FATJ; HKLLS2; NBLA00548; VMLDS2
UniProt ID: (Human) Q6V0I7
Entrez Gene ID: (Human) 79633
branching involved in ureteric bud morphogenesis
heart morphogenesis
plasma membrane organization
homophilic cell adhesion via plasma membrane adhesion molecules
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
cerebral cortex development
neurogenesis
hippo signaling
ossification involved in bone maturation
digestive tract development
inner ear receptor stereocilium organization
regulation of metanephric nephron tubule epithelial cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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