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Invitrogen
FAT4 Polyclonal Antibody
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Product Details
PA5-116735
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 4900-4981 of human FAT4 (NP_0788584)
Conjugate
Form
Liquid
Concentration
1.58 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2901366
Product Specific Information
Positive Samples: U-87MG
Immunogen sequence: GGPVGTQAAA PGTADNTLPM KLGQQAGTFN WDNLLNWGPG FGHYVDVFKD LASLPEKAAA NEEGKAGTTK PVPKDGEAEQ YV
Target Information
FAT1, FAT2, FAT3 and FAT4 are human homologs of Drosophila Fat, which is involved in tumor suppression and planar cell polarity (PCP). FAT4 undergo the first proteolytic cleavage by Furin and are predicted to undergo the second cleavage by secretase to release intracellular domain (ICD). FAT4 directly interacts with MPDZ/MUPP1 to recruit membrane associated guanylate kinase MPP5/PALS1. FAT4 is involved in the maintenance of PCP and inhibition of cell proliferation.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cadherin family member 14; cadherin-related family member 11; FAT tumor suppressor homolog 4; Fat-like cadherin protein FAT-J; hFat4; Protocadherin Fat 4; putative protein product of Nbla00548
Gene Aliases: 6030410K14Rik; 9430004M15; CDHF14; CDHR11; FAT-J; FAT4; FATJ; HKLLS2; NBLA00548; RGD1564291; VMLDS2
UniProt ID: (Human) Q6V0I7, (Mouse) Q2PZL6
Entrez Gene ID: (Human) 79633, (Rat) 310341, (Mouse) 329628
branching involved in ureteric bud morphogenesis
kidney development
heart morphogenesis
plasma membrane organization
homophilic cell adhesion via plasma membrane adhesion molecules
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
cerebral cortex development
neurogenesis
hippo signaling
ossification involved in bone maturation
digestive tract development
inner ear receptor stereocilium organization
regulation of metanephric nephron tubule epithelial cell differentiation
establishment of planar polarity
cell adhesion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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