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FAT4 Antibody (MA5-37780) in WB
Western Blot analysis of FAT4 using the FAT4 Monoclonal Antibody (Product # MA5-37780) at a 1:2000 dilution. Recombinant protein at 20 ng per lane. Secondary Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1:10,000 dilution. Predicted band size: 543 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.
Product Details
MA5-37780
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
1654CT892.85.3
Immunogen
recombinant protein between 4500-4786 amino acids from human FAT4
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2897704
Target Information
FAT1, FAT2, FAT3 and FAT4 are human homologs of Drosophila Fat, which is involved in tumor suppression and planar cell polarity (PCP). FAT4 undergo the first proteolytic cleavage by Furin and are predicted to undergo the second cleavage by secretase to release intracellular domain (ICD). FAT4 directly interacts with MPDZ/MUPP1 to recruit membrane associated guanylate kinase MPP5/PALS1. FAT4 is involved in the maintenance of PCP and inhibition of cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cadherin family member 14; cadherin-related family member 11; FAT tumor suppressor homolog 4; Fat-like cadherin protein FAT-J; hFat4; Protocadherin Fat 4; putative protein product of Nbla00548
Gene Aliases: CDHF14; CDHR11; FAT-J; FAT4; FATJ; HKLLS2; NBLA00548; VMLDS2
UniProt ID: (Human) Q6V0I7
Entrez Gene ID: (Human) 79633
branching involved in ureteric bud morphogenesis
heart morphogenesis
plasma membrane organization
homophilic cell adhesion via plasma membrane adhesion molecules
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
cerebral cortex development
neurogenesis
hippo signaling
ossification involved in bone maturation
digestive tract development
inner ear receptor stereocilium organization
regulation of metanephric nephron tubule epithelial cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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