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Invitrogen
FBXO32 Polyclonal Antibody
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FBXO32 Antibody (PA5-106917) in IHC (P)
Immunohistochemistry analysis of FBXO32 in rat heart tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with FBXO32 polyclonal antibody (Product # PA5-106917) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-106917
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human FBXO32(Accession Q969P5), corresponding to amino acid residues N50-L100.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2854581
Product Specific Information
Antibody detects endogenous levels of total FBXO32.
Target Information
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs, which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing of this gene results in two transcript variants encoding two isoforms of different sizes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: atrogin 1; Atrogin-1; atrophy gene 1; F-box only protein 32; fbxo25; FLJ32424; MAFbx; MGC108443; MGC137646; MGC33610; Muscle atrophy F-box protein
Gene Aliases: 4833442G10Rik; AI430017; ATROGIN1; Fbx32; FBXO32; Gm20361; MAFbx
UniProt ID: (Human) Q969P5, (Rat) Q91Z62, (Mouse) Q9CPU7
Entrez Gene ID: (Human) 114907, (Rat) 171043, (Mouse) 67731
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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