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Bioss
FBXO45 Polyclonal Antibody
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FIGURE: 1 / 3
FBXO45 Antibody (BS-13150R) in IHC (P)
Paraformaldehyde-fixed, paraffin-embedded Mouse Brain; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with FBXO45 Polyclonal Antibody, Unconjugated (bs-13150R) at 1:200 overnight at 4°C, followed by secondary and DAB staining.
Product Details
BS-13150R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human FBXO45, amino acids 110-210.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Component of E3 ubiquitin ligase complexes. Required for normal neuromuscular synaptogenesis, axon pathfinding and neuronal migration. Plays a role in the regulation of neurotransmission at mature neurons. May controls synaptic activity by controlling UNC13A via ubiquitin dependent pathway. Specifically recognizes TP73, promoting its ubiquitination and degradation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: F-box only protein 45; F-box protein 45; F-box/SPRY domain-containing protein 1; fbxo45; hFbxo45; mFbxo45
Gene Aliases: 2610017J04Rik; AI463119; BC026799; FBX45; FBXO45; RGD1311861
UniProt ID: (Human) P0C2W1, (Mouse) Q8K3B1
Entrez Gene ID: (Human) 200933, (Mouse) 268882, (Rat) 288042
neuron migration
cellular response to DNA damage stimulus
multicellular organism development
nervous system development
protein ubiquitination
cerebral cortex radially oriented cell migration
cerebral cortex tangential migration
corticospinal tract morphogenesis
anterior commissure morphogenesis
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
proteasome-mediated ubiquitin-dependent protein catabolic process
innervation
synapse assembly involved in innervation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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