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FBXW11 Polyclonal Antibody

FBXW11 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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FBXW11 Antibody (13149-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human stomach cancer tissue slide using 13149-1-AP ( FBXW11 Antibody) at dilution of 1:100 (under 40x lens).

FBXW11 Antibody in Immunoprecipitation (IP)

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Product Details

13149-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 11 publications 11 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

FBXW11 Fusion Protein Ag3761 (216-529 aa encoded by BC026213)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.16 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: NLQRIQCRS ENSKGVYCLQ YDDEKIISGL RDNSIKIWDK TSLECLKVLT GHTGSVLCLQ YDERVIVTGS SDSTVRVWDV NTGEVLNTLI HHNEAVLHLR FSNGLMVTCS KDRSIAVWDM ASATDITLRR VLVGHRAAVN VVDFDDKYIV SASGDRTIKV WSTSTCEFVR TLNGHKRGIA CLQYRDRLVV SGSSDNTIRL WDIECGACLR VLEGHEELVR CIRFDNKRIV SGAYDGKIKV WDLQAALDPR APASTLCLRT LVEHSGRVFR LQFDEFQIIS SSHDDTILIW DFLNVPPSAQ NETRSPSRTY TYISR (216-529 aa encoded by BC026213)

Target Information

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

A yes-associated protein 1- Notch1 receptor positive feedback loop promotes breast cancer lung metastasis by attenuating the bone morphogenetic protein 4-SMAD family member 1/5 signaling.

Carcinogenesis

Zhao L,Lei J,Gu S,Zhang Y,Jing X,Wang L,Zhang L,Ning Q,Luo M,Qi Y,Zhao X,Shao S

Sat Dec 31 00:00:00 UTC 2022

Association of FBXW11 levels with tumor development and prognosis in chondrosarcoma.

Cancer biomarkers : section A of Disease markers

Chen C,Zhou H,Zhang X,Liu Z,Ma X

Tue Dec 27 00:00:00 UTC 2022

Association of FBXW11 levels with tumor development and prognosis in chondrosarcoma.

Cancer biomarkers : section A of Disease markers

Chen C,Zhou H,Zhang X,Liu Z,Ma X

Tue Dec 27 00:00:00 UTC 2022

NUMB facilitates autophagy initiation through targeting SCF^β-TrCP2 complex.

Cell death and differentiation

Li H,Shu S,Zhou M,Chen Y,Xiao A,Ma Y,Zhu F,Hu Z,Nie J

Fri Jul 01 00:00:00 UTC 2022

uc.77- Downregulation Promotes Colorectal Cancer Cell Proliferation by Inhibiting FBXW8-Mediated CDK4 Protein Degradation.

Frontiers in oncology

Zheng Z,Hong D,Zhang X,Chang Y,Sun N,Lin Z,Li H,Huang S,Zhang R,Xie Q,Huang H,Jin H

Tue Jun 08 00:00:00 UTC 2021

Dysregulation of Zinc Finger Protein 395 Contributes to the Pathogenesis of Chondrosarcoma.

OncoTargets and therapy

Chen C,Zhou H,Liu Z,Ma X

Sat Apr 23 00:00:00 UTC 2022

MK2 promotes Tfcp2l1 degradation via β-TrCP ubiquitin ligase to regulate mouse embryonic stem cell self-renewal.

Cell reports

Zhang Y,Ding H,Wang X,Wang X,Wan S,Xu A,Gan R,Ye SD

Tue Nov 02 00:00:00 UTC 2021

MK2 promotes Tfcp2l1 degradation via β-TrCP ubiquitin ligase to regulate mouse embryonic stem cell self-renewal.

Cell reports

Zhang Y,Ding H,Wang X,Wang X,Wan S,Xu A,Gan R,Ye SD

Tue Nov 02 00:00:00 UTC 2021

Role of miR-214 in regulation of β-catenin and the malignant phenotype of melanoma.

Molecular carcinogenesis

Prabhakar K,Rodrίguez CI,Jayanthy AS,Mikheil DM,Bhasker AI,Perera RJ,Setaluri V

Fri Nov 01 00:00:00 UTC 2019

CUL7 E3 Ubiquitin Ligase Mediates the Degradation of Activation-Induced Cytidine Deaminase and Regulates the Ig Class Switch Recombination in B Lymphocytes.

Journal of immunology (Baltimore, Md. : 1950)

Luo Y,Liu Y,Wu L,Ma X,Liu Q,Huang F,Zhang X,Zhang Y,Zhang J,Luo H,Yang Y,Lu G,Tang X,Li L,Zeng Y,Pan T,Zhang H

Mon Jul 01 00:00:00 UTC 2019

MiR-182 promotes cell proliferation by suppressing FBXW7 and FBXW11 in non-small cell lung cancer.

American journal of translational research

Chang H,Liu YH,Wang LL,Wang J,Zhao ZH,Qu JF,Wang SF

Wed Sep 30 00:00:00 UTC 2020

MiR-182 promotes cell proliferation by suppressing FBXW7 and FBXW11 in non-small cell lung cancer.

American journal of translational research

Chang H,Liu YH,Wang LL,Wang J,Zhao ZH,Qu JF,Wang SF

Wed Sep 30 00:00:00 UTC 2020

The E3 ubiquitin ligase APC/C^C^dh1 degrades MCPH1 after MCPH1-βTrCP2-Cdc25A-mediated mitotic entry to ensure neurogenesis.

The EMBO journal

Liu X,Zong W,Li T,Wang Y,Xu X,Zhou ZW,Wang ZQ

Fri Dec 15 00:00:00 UTC 2017

The E3 ubiquitin ligase APC/C^C^dh1 degrades MCPH1 after MCPH1-βTrCP2-Cdc25A-mediated mitotic entry to ensure neurogenesis.

The EMBO journal

Liu X,Zong W,Li T,Wang Y,Xu X,Zhou ZW,Wang ZQ

Fri Dec 15 00:00:00 UTC 2017

The E3 ubiquitin ligase APC/C^C^dh1 degrades MCPH1 after MCPH1-βTrCP2-Cdc25A-mediated mitotic entry to ensure neurogenesis.

The EMBO journal

Liu X,Zong W,Li T,Wang Y,Xu X,Zhou ZW,Wang ZQ

Fri Dec 15 00:00:00 UTC 2017

The E3 ubiquitin ligase APC/C^C^dh1 degrades MCPH1 after MCPH1-βTrCP2-Cdc25A-mediated mitotic entry to ensure neurogenesis.

The EMBO journal

Liu X,Zong W,Li T,Wang Y,Xu X,Zhou ZW,Wang ZQ

Fri Dec 15 00:00:00 UTC 2017

The β-TrCP-FBXW2-SKP2 axis regulates lung cancer cell growth with FBXW2 acting as a tumour suppressor.

Nature communications

Xu J,Zhou W,Yang F,Chen G,Li H,Zhao Y,Liu P,Li H,Tan M,Xiong X,Sun Y

Mon Jan 16 00:00:00 UTC 2017

The β-TrCP-FBXW2-SKP2 axis regulates lung cancer cell growth with FBXW2 acting as a tumour suppressor.

Nature communications

Xu J,Zhou W,Yang F,Chen G,Li H,Zhao Y,Liu P,Li H,Tan M,Xiong X,Sun Y

Mon Jan 16 00:00:00 UTC 2017

DNA damage regulates UHRF1 stability via the SCF(β-TrCP) E3 ligase.

Molecular and cellular biology

Chen H,Ma H,Inuzuka H,Diao J,Lan F,Shi YG,Wei W,Shi Y

Fri Mar 01 00:00:00 UTC 2013

DNA damage regulates UHRF1 stability via the SCF(β-TrCP) E3 ligase.

Molecular and cellular biology

Chen H,Ma H,Inuzuka H,Diao J,Lan F,Shi YG,Wei W,Shi Y

Fri Mar 01 00:00:00 UTC 2013

Bioinformatics

Protein Aliases: beta-transducin repeat-containing protein 2; F-box and WD repeats protein beta-TrCP2; F-box and WD-40 domain protein 11; F-box and WD-40 domain protein 1B; F-box protein Fbw1b; F-box/WD repeat-containing protein 11; F-box/WD repeat-containing protein 1B; Homologous to Slimb protein; HOS

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Gene Aliases: 2310065A07Rik; AA536858; BTRC2; BTRCP2; Fbw11; FBW1B; FBXW11; FBXW1B; HOS; KIAA0696

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UniProt ID: (Human) Q9UKB1, (Mouse) Q5SRY7

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Entrez Gene ID: (Human) 23291, (Mouse) 103583

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Function(s)

ubiquitin-protein transferase activity protein binding protein dimerization activity ubiquitin protein ligase activity

Process(es)

protein polyubiquitination protein dephosphorylation cell cycle Wnt signaling pathway protein ubiquitination SCF-dependent proteasomal ubiquitin-dependent protein catabolic process protein destabilization negative regulation of NF-kappaB import into nucleus positive regulation of circadian rhythm proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of proteolysis negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated rhythmic process G2/M transition of mitotic cell cycle stimulatory C-type lectin receptor signaling pathway NIK/NF-kappaB signaling Fc-epsilon receptor signaling pathway T cell receptor signaling pathway stress-activated MAPK cascade

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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FBXW11 Polyclonal Antibody

FBXW11 Antibody (13149-1-AP) in IHC (P)

Product Details

13149-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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