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Invitrogen
FBXW8 Polyclonal Antibody
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Product Details
PA5-116803
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 500-598 of human FBXW8 (NP_6991792)
Conjugate
Form
Liquid
Concentration
1.46 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2901434
Product Specific Information
Positive Samples: U-87MG, A-549, A-431, Rat lung, Rat heart
Immunogen sequence: WDYRMNQKLW EVYSGHPVQH ISFSSHSLIT ANVPYQTVMR NADLDSFTTH RRHRGLIRAY EFAVDQLAFQ SPLPVCRSSC DAMATHYYDL ALAFPYNHV
Target Information
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: F-box and WD-40 domain protein 8; F-box and WD-40 domain-containing protein 8; F-box only protein 29; F-box protein FBX29; F-box/WD repeat-containing protein 8; MGC33534
Gene Aliases: 4930438M06Rik; FBW6; FBW8; FBX29; FBXO29; FBXW6; FBXW8
UniProt ID: (Human) Q8N3Y1, (Mouse) Q8BIA4
Entrez Gene ID: (Human) 26259, (Rat) 304522, (Mouse) 231672
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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