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FDFT1 Polyclonal Antibody

FDFT1 Antibody in Immunocytochemistry (ICC/IF)

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FDFT1 Antibody (13128-1-AP) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol ) fixed L02 cells using 13128-1-AP (FDFT1 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

FDFT1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FDFT1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

13128-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 12 publications 12 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:50-1:500

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

FDFT1 Fusion Protein Ag3743 (1-358 aa encoded by BC029641)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MEFVKCLGH PEEFYNLVRF RIGGKRKVMP KMDQDSLSSS LKTCYKYLNQ TSRSFAAVIQ ALDGEMRNAV CIFYLVLRAL DTLEDDMTIS VEKKVPLLHN FHSFLYQPDW RFMESKEKDR QVLEDFPTIS LEFRNLAEKY QTVIADICRR MGIGMAEFLD KHVTSEQEWD KYCHYVAGLV GIGLSRLFSA SEFEDPLVGE DTERANSMGL FLQKTNIIRD YLEDQQGGRE FWPQEVWSRY VKKLGDFAKP ENIDLAVQCL NELITNALHH IPDVITYLSR LRNQSVFNFC AIPQVMAIAT LAACYNNQQV FKGAVKIRKG QAVTLMMDAT NMPAVKAIIY QYMEEIYHRI PDSDPSSSK (1-358 aa encoded by BC029641 )

Target Information

FDFT1 catalyzes the first step in the cholesterol biosynthetic pathway, the conversion of trans-farnesyldiphosphate to squalene. The loss of promoter activity and response to sterols for FDFT1 is localized to a 69-bp section positioned 131 bp 5-prime to the transcription start site. Sequence analysis of this region shows that it contains a sterol regulatory element-1 (SRE1) previously identified in other sterol regulated genes and 2 putative NF1 binding sites.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Caffeine Supplementation and FOXM1 Inhibition Enhance the Antitumor Effect of Statins in Neuroblastoma.

Cancer research

Tran GB,Ding J,Ye B,Liu M,Yu Y,Zha Y,Dong Z,Liu K,Sudarshan S,Ding HF

Wed Jul 05 00:00:00 UTC 2023

MiR-122-5p regulates the mevalonate pathway by targeting p53 in non-small cell lung cancer.

Cell death & disease

Zheng YK,Zhou ZS,Wang GZ,Tu JY,Cheng HB,Ma SZ,Ke C,Wang Y,Jian QP,Shu YH,Wu XW

Sat Apr 01 00:00:00 UTC 2023

MiR-122-5p regulates the mevalonate pathway by targeting p53 in non-small cell lung cancer.

Cell death & disease

Zheng YK,Zhou ZS,Wang GZ,Tu JY,Cheng HB,Ma SZ,Ke C,Wang Y,Jian QP,Shu YH,Wu XW

Sat Apr 01 00:00:00 UTC 2023

Identification of FDFT1 as a potential biomarker associated with ferroptosis in ccRCC.

Cancer medicine

Huang R,Zhang C,Wang X,Zou X,Xiang Z,Wang Z,Gui B,Lin T,Hu H

Tue Nov 01 00:00:00 UTC 2022

Therapeutic targeting of the mevalonate-geranylgeranyl diphosphate pathway with statins overcomes chemotherapy resistance in small cell lung cancer.

Nature cancer

Guo C,Wan R,He Y,Lin SH,Cao J,Qiu Y,Zhang T,Zhao Q,Niu Y,Jin Y,Huang HY,Wang X,Tan L,Thomas RK,Zhang H,Chen L,Wong KK,Hu L,Ji H

Sun May 01 00:00:00 UTC 2022

Schwann Cells Accelerate Osteogenesis via the Mif/CD74/FOXO1 Signaling Pathway In Vitro.

Stem cells international

Li JQ,Jiang HJ,Su XY,Feng L,Zhan NZ,Li SS,Chen ZJ,Chang BH,Cheng PZ,Yang L,Pei GX

Tue Jan 25 00:00:00 UTC 2022

Squalene synthase predicts poor prognosis in stage I-III colon adenocarcinoma and synergizes squalene epoxidase to promote tumor progression.

Cancer science

Jiang H,Tang E,Chen Y,Liu H,Zhao Y,Lin M,He L

Tue Mar 01 00:00:00 UTC 2022

Squalene synthase predicts poor prognosis in stage I-III colon adenocarcinoma and synergizes squalene epoxidase to promote tumor progression.

Cancer science

Jiang H,Tang E,Chen Y,Liu H,Zhao Y,Lin M,He L

Tue Mar 01 00:00:00 UTC 2022

Hibiscus syriacus L. cultivated in callus culture exerts cytotoxicity in colorectal cancer via Notch signaling-mediated cholesterol biosynthesis suppression.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Xu XY,Choi HS,Park SY,Kim JK,Seo KH,Kim H,Kim YJ

Sat Jan 01 00:00:00 UTC 2022

Functional Genomics Identifies Metabolic Vulnerabilities in Pancreatic Cancer.

Cell metabolism

Biancur DE,Kapner KS,Yamamoto K,Banh RS,Neggers JE,Sohn ASW,Wu W,Manguso RT,Brown A,Root DE,Aguirre AJ,Kimmelman AC

Tue Jan 05 00:00:00 UTC 2021

Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory.

Neuron

Li X,Zhang J,Li D,He C,He K,Xue T,Wan L,Zhang C,Liu Q

Wed Mar 17 00:00:00 UTC 2021

20(S)-Rg3 upregulates FDFT1 via reducing miR-4425 to inhibit ovarian cancer progression.

Archives of biochemistry and biophysics

Lu J,Zhou Y,Zheng X,Chen L,Tuo X,Chen H,Xue M,Chen Q,Chen W,Li X,Zhao L

Fri Oct 30 00:00:00 UTC 2020

20(S)-Rg3 upregulates FDFT1 via reducing miR-4425 to inhibit ovarian cancer progression.

Archives of biochemistry and biophysics

Lu J,Zhou Y,Zheng X,Chen L,Tuo X,Chen H,Xue M,Chen Q,Chen W,Li X,Zhao L

Fri Oct 30 00:00:00 UTC 2020

Feeding induces cholesterol biosynthesis via the mTORC1-USP20-HMGCR axis.

Nature

Lu XY,Shi XJ,Hu A,Wang JQ,Ding Y,Jiang W,Sun M,Zhao X,Luo J,Qi W,Song BL

Tue Dec 01 00:00:00 UTC 2020

A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition.

Nature communications

Mahoney CE,Pirman D,Chubukov V,Sleger T,Hayes S,Fan ZP,Allen EL,Chen Y,Huang L,Liu M,Zhang Y,McDonald G,Narayanaswamy R,Choe S,Chen Y,Gross S,Cianchetta G,Padyana AK,Murray S,Liu W,Marks KM,Murtie J,Dorsch M,Jin S,Nagaraja N,Biller SA,Roddy T,Popovici-Muller J,Smolen GA

Wed Jan 09 00:00:00 UTC 2019

A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition.

Nature communications

Wed Jan 09 00:00:00 UTC 2019

Bioinformatics

Protein Aliases: Farnesyl-diphosphate farnesyltransferase; Farnesyl-diphosphate farnesyltransferase 1; FPP:FPP farnesyltransferase; presqualene-di-diphosphate synthase; SQS; Squalene synthase; squalene synthetase

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Gene Aliases: DGPT; ERG9; FDFT1; SQS; SS

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UniProt ID: (Human) P37268

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Entrez Gene ID: (Human) 2222

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Function(s)

farnesyl-diphosphate farnesyltransferase activity oxidoreductase activity squalene synthase activity

Process(es)

steroid biosynthetic process cholesterol biosynthetic process isoprenoid biosynthetic process farnesyl diphosphate metabolic process oxidation-reduction process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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FDFT1 Polyclonal Antibody

FDFT1 Antibody (13128-1-AP) in ICC/IF

Product Details

13128-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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