Proteintech

FDPS Polyclonal Antibody

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FDPS Antibody (16129-1-AP) in WB

HepG2 cells were subjected to SDS PAGE followed by western blot with (Product # 16129-1-AP) FDPS antibody at dilution of 1:4,000 incubated at room temperature for 1.5 hours.

FDPS Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

16129-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

View 11 publications 11 publications

Immunohistochemistry (IHC)

Assay-dependent

View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

FDPS Fusion Protein Ag9115 (68-419 aa encoded by BC010004)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.23 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Western blot analysis using this antibody detected a major band around 41 kDa in mouse liver tissue.

Immunogen sequence: NGDQNSDVY AQEKQDFVQH FSQIVRVLTE DEMGHPEIGD AIARLKEVLE YNAIGGKYNR GLTVVVAFRE LVEPRKQDAD SLQRAWTVGW CVELLQAFFL VADDIMDSSL TRRGQICWYQ KPGVGLDAIN DANLLEACIY RLLKLYCREQ PYYLNLIELF LQSSYQTEIG QTLDLLTAPQ GNVDLVRFTE KRYKSIVKYK TAFYSFYLPI AAAMYMAGID GEKEHANAKK ILLEMGEFFQ IQDDYLDLFG DPSVTGKIGT DIQDNKCSWL VVQCLQRATP EQYQILKENY GQKEAEKVAR VKALYEELDL PAVFLQYEED SYSHIMALIE QYAAPLPPAV FLGLARKIYK RRK (68-419 aa encoded by BC010004)

Target Information

The isoprene biosynthetic pathway supply the cell with cholesterol, ubiquinone, and various nonsterol metabolites. The farnesylpyrophosphate synthetase enzyme catalyzes the formation of geranyl and farnesylpyrophosphate from isopentenylpyrophosphate and dimethylallyl pyrophosphate. Analysis of FDPS activity and protein in rat liver, accompanied by immunofluorescence and immunoelectron microscopy studies, demonstrated that FDPS is predominantly localized in peroxisomes. 1 Liver tissue from patients with the peroxisomal deficiency diseases Zellweger syndrome and neonatal adrenoleukodystrophy exhibit diminished activities of FDPS and subsequent isoprenoid synthesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Therapeutic targeting of the mevalonate-geranylgeranyl diphosphate pathway with statins overcomes chemotherapy resistance in small cell lung cancer.

Nature cancer

Guo C,Wan R,He Y,Lin SH,Cao J,Qiu Y,Zhang T,Zhao Q,Niu Y,Jin Y,Huang HY,Wang X,Tan L,Thomas RK,Zhang H,Chen L,Wong KK,Hu L,Ji H

Sun May 01 00:00:00 UTC 2022

Cholesterol biosynthesis defines oligodendrocyte precursor heterogeneity between brain and spinal cord.

Cell reports

Khandker L,Jeffries MA,Chang YJ,Mather ML,Evangelou AV,Bourne JN,Tafreshi AK,Ornelas IM,Bozdagi-Gunal O,Macklin WB,Wood TL

Tue Mar 01 00:00:00 UTC 2022

Disruption of FDPS/Rac1 axis radiosensitizes pancreatic ductal adenocarcinoma by attenuating DNA damage response and immunosuppressive signalling.

EBioMedicine

Seshacharyulu P,Halder S,Nimmakayala R,Rachagani S,Chaudhary S,Atri P,Chirravuri-Venkata R,Ouellette MM,Carmicheal J,Gautam SK,Vengoji R,Wang S,Li S,Smith L,Talmon GA,Klute K,Ly Q,Reames BN,Grem JL,Berim L,Padussis JC,Kaur S,Kumar S,Ponnusamy MP,Jain M,Lin C,Batra SK

Sat Jan 01 00:00:00 UTC 2022

Disruption of FDPS/Rac1 axis radiosensitizes pancreatic ductal adenocarcinoma by attenuating DNA damage response and immunosuppressive signalling.

EBioMedicine

Sat Jan 01 00:00:00 UTC 2022

Transcriptomic Analysis Reveals the Protective Effects of Empagliflozin on Lipid Metabolism in Nonalcoholic Fatty Liver Disease.

Frontiers in pharmacology

Ma Y,Kan C,Qiu H,Liu Y,Hou N,Han F,Shi J,Sun X

Sat Jan 08 00:00:00 UTC 2022

Simvastatin accelerated motoneurons death in SOD1^G93A mice through inhibiting Rab7-mediated maturation of late autophagic vacuoles.

Cell death & disease

Bai L,Wang Y,Huo J,Li S,Wen Y,Liu Q,Yang J,Liu Y,Li R

Mon Apr 12 00:00:00 UTC 2021

Rapamycin regulates cholesterol biosynthesis and cytoplasmic ribosomal proteins in hippocampus and temporal lobe of APP/PS1 mouse.

Journal of the neurological sciences

Wang X,Xia W,Li K,Zhang Y,Ge W,Ma C

Mon Apr 15 00:00:00 UTC 2019

Overexpression of farnesyl pyrophosphate synthase increases myocardial ischemia/reperfusion injury in mice.

Gene

Dai D,Sun X,Ding J,Chen Y,Hu S

Tue Sep 25 00:00:00 UTC 2018

Overexpression of farnesyl pyrophosphate synthase increases myocardial ischemia/reperfusion injury in mice.

Gene

Dai D,Sun X,Ding J,Chen Y,Hu S

Tue Sep 25 00:00:00 UTC 2018

Does Viperin Function as a Radical S-Adenosyl-l-methionine-dependent Enzyme in Regulating Farnesylpyrophosphate Synthase Expression and Activity?

The Journal of biological chemistry

Makins C,Ghosh S,Román-Meléndez GD,Malec PA,Kennedy RT,Marsh EN

Fri Dec 23 00:00:00 UTC 2016

Lentiviral-mediated silencing of farnesyl pyrophosphate synthase through RNA interference in mice.

BioMed research international

Yang J,Zhao CZ,Chen B,Chen F,Han J,Hu SJ

Mon Sep 28 00:00:00 UTC 2015

Lentiviral-mediated silencing of farnesyl pyrophosphate synthase through RNA interference in mice.

BioMed research international

Yang J,Zhao CZ,Chen B,Chen F,Han J,Hu SJ

Mon Sep 28 00:00:00 UTC 2015

Cardiac-specific overexpression of farnesyl pyrophosphate synthase induces cardiac hypertrophy and dysfunction in mice.

Cardiovascular research

Yang J,Mou Y,Wu T,Ye Y,Jiang JC,Zhao CZ,Zhu HH,Du CQ,Zhou L,Hu SJ

Fri Mar 01 00:00:00 UTC 2013

Cardiac-specific overexpression of farnesyl pyrophosphate synthase induces cardiac hypertrophy and dysfunction in mice.

Cardiovascular research

Yang J,Mou Y,Wu T,Ye Y,Jiang JC,Zhao CZ,Zhu HH,Du CQ,Zhou L,Hu SJ

Fri Mar 01 00:00:00 UTC 2013

Cardiac-specific overexpression of farnesyl pyrophosphate synthase induces cardiac hypertrophy and dysfunction in mice.

Cardiovascular research

Yang J,Mou Y,Wu T,Ye Y,Jiang JC,Zhao CZ,Zhu HH,Du CQ,Zhou L,Hu SJ

Fri Mar 01 00:00:00 UTC 2013

Cardiac-specific overexpression of farnesyl pyrophosphate synthase induces cardiac hypertrophy and dysfunction in mice.

Cardiovascular research

Yang J,Mou Y,Wu T,Ye Y,Jiang JC,Zhao CZ,Zhu HH,Du CQ,Zhou L,Hu SJ

Fri Mar 01 00:00:00 UTC 2013

Inhibition of farnesyl pyrophosphate synthase attenuates angiotensin II-induced cardiac hypertrophy and fibrosis in vivo.

The international journal of biochemistry & cell biology

Yang J,Zhu HH,Chen GP,Ye Y,Zhao CZ,Mou Y,Hu SJ

Fri Mar 01 00:00:00 UTC 2013

Inhibition of farnesyl pyrophosphate synthase attenuates angiotensin II-induced cardiac hypertrophy and fibrosis in vivo.

The international journal of biochemistry & cell biology

Yang J,Zhu HH,Chen GP,Ye Y,Zhao CZ,Mou Y,Hu SJ

Fri Mar 01 00:00:00 UTC 2013

Bioinformatics

Protein Aliases: (2E,6E)-farnesyl diphosphate synthase; Cholesterol-regulated 39 kDa protein; CR 39; Dimethylallyltranstransferase; Farnesyl diphosphate synthase; farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase); farnesyl diphosphate synthetase; Farnesyl pyrophosphate synthase; farnesyl pyrophosphate synthetase; farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase; FPP synthase; FPP synthetase; FPS; Geranyltranstransferase; testis-specific farnesyl pyrophosphate synthetase

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Gene Aliases: 6030492I17Rik; Ac2-125; AI256750; FDPS; Fdpsl1; FPPS; FPS; KIAA1293; mKIAA1293; POROK9

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UniProt ID: (Human) P14324, (Rat) P05369, (Mouse) Q920E5

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Entrez Gene ID: (Human) 2224, (Rat) 83791, (Mouse) 110196

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Function(s)

dimethylallyltranstransferase activity geranyltranstransferase activity poly(A) RNA binding metal ion binding farnesyltranstransferase activity transferase activity

Process(es)

cholesterol biosynthetic process spermatogenesis isoprenoid biosynthetic process male gonad development geranyl diphosphate biosynthetic process response to testosterone response to drug response to peptide hormone farnesyl diphosphate biosynthetic process positive regulation of cholesterol biosynthetic process positive regulation of cell growth involved in cardiac muscle cell development response to cholesterol cellular response to fatty acid viral process lipid metabolic process steroid biosynthetic process steroid metabolic process cholesterol metabolic process sterol biosynthetic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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FDPS Polyclonal Antibody

FDPS Antibody (16129-1-AP) in WB

Product Details

16129-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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