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Product Details
11030-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
FEM1B Fusion Protein Ag1497 (279-627 aa encoded by BC010122)
Conjugate
Form
Liquid
Concentration
0.33 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: AMLERFQDG DNILEKEVLP PIHAYGNRTE CRNPQELESI RQDRDALHME GLIVRERILG ADNIDVSHPI IYRGAVYADN MEFEQCIKLW LHALHLRQKG NRNTHKDLLR FAQVFSQMIH LNETVKAPDI ECVLRCSVLE IEQSMNRVKN ISDADVHNAM DNYECNLYTF LYLVCISTKT QCSEEDQCKI NKQIYNLIHL DPRTREGFTL LHLAVNSNTP VDDFHTNDVC SFPNALVTKL LLDCGAEVNA VDNEGNSALH IIVQYNRPIS DFLTLHSIII SLVEAGAHTD MTNKQNKTPL DKSTTGVSEI LLKTQMKMSL KCLAARAVRA NDINYQDQIP RTLEEFVGFH (279-627 aa encoded by BC010122)
Target Information
Fas and tumor necrosis factor receptor 1 (TNFR1) are two prototype members in the death receptor family. A novel protein that associates with the intracellular domains of Fas and TNFR1 was recently identified and designated F1Aalpha and FEM1-b. F1Aalpha/FEM1-b is the homologue of C. elegans sex determining protein FEM-1. FEM-1/F1Aalpha is cleaved by CED-3 and caspase. FEM-1/F1Aalpha associates with CED-4 and its mammalian homologue Apaf-1. Overexpression of F1Aalpha induces apoptosis. F1Aalpha is therefore a novel member of the death receptor associated protein that mediates apoptosis. F1Aalpha is expressed in a variety of human and mouse tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp451E0710; F1A-alpha; FEM-1-like death receptor binding protein; Fem-1-like death receptor-binding protein alpha; Fem-1-like in apoptotic pathway protein alpha; FEM1-beta; FEM1b; feminization 1 homolog b; FIAA; mt-Fem; Protein fem-1 homolog B
Gene Aliases: F1A-ALPHA; F1AA; FEM1-beta; FEM1B; KIAA0396; mKIAA0396
UniProt ID: (Human) Q9UK73, (Mouse) Q9Z2G0, (Rat) P0C6P7
Entrez Gene ID: (Human) 10116, (Mouse) 14155, (Rat) 315745
epithelial cell maturation
apoptotic process
protein ubiquitination
regulation of ubiquitin-protein transferase activity
branching involved in prostate gland morphogenesis
epithelial cell maturation involved in prostate gland development
regulation of extrinsic apoptotic signaling pathway via death domain receptors
regulation of DNA damage checkpoint
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