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Invitrogen
FES Polyclonal Antibody
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FIGURE: 1 / 1
FES Antibody (PA5-96171) in WB
Western blot analysis of FES in extracts of various cell lines. Samples were incubated with FES Polyclonal antibody (Product # PA5-96171) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST.
Product Details
PA5-96171
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 120-420 of human FES (NP_0011372561)
Conjugate
Form
Liquid
Concentration
0.19 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2807973
Product Specific Information
Immunogen sequence: WQQLQQELTK THSQDIEKLK SQYRALARDS AQAKRKYQEA SKDKDRDKAK DKYVRSLWKL FAHHNRYVLG VRAAQLHHQH HHQLLLPGLL RSLQDLHEEM ACILKEILQE YLEISSLVQD EVVAIHREMA AAAARIQPEA EYQGFLRQYG SAPDVPPCVT FDESLLEEGE PLEPGELQLN ELTVESVQHT LTSVTDELAV ATEMVFRRQE MVTQLQQELR NEEENTHPRE RVQLLGKRQV LQEALQGLQV ALCSQAKLQA QQELLQTKLE HLGPGEPPPV LLLQDDRHST SSSEQEREGG R; Positive Samples: Mouse heart, Mouse brain; Cellular Location: Cell junction, Cell membrane, Cytoplasm, Cytoplasmic side, Cytoplasmic vesicle, Golgi apparatus, Peripheral membrane protein, cytoskeleton, cytosol, focal adhesion
Target Information
FES (FPS) is a tyrosine protein kinase that is required for maintenance of cellular transformation. Its chromosomal location is linked to a specific translocation event identified in patients with acute promyelocytic leukemia, and it is also involved in normal hematopoiesis. Alternative splicing results in multiple variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EC 2.7.10.2; Proto-oncogene c-Fes; proto-oncogene tyrosine-protein kinase Fes/Fps; tyrosine kinase Fps/Fes; Tyrosine-protein kinase Fes/Fps; Variant 4
Gene Aliases: AI586313; BB137047; c-fes; Fes; FPS
UniProt ID: (Mouse) P16879
Entrez Gene ID: (Mouse) 14159
nucleotide binding
protein kinase activity
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
receptor binding
protein binding
ATP binding
microtubule binding
lipid binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
immunoglobulin receptor binding
phosphatidylinositol binding
microtubule bundle formation
protein phosphorylation
chemotaxis
cell adhesion
transmembrane receptor protein tyrosine kinase signaling pathway
regulation of cell shape
positive regulation of neuron projection development
phosphorylation
cell migration
peptidyl-tyrosine phosphorylation
cell differentiation
regulation of cell adhesion
positive regulation of microtubule polymerization
peptidyl-tyrosine autophosphorylation
regulation of cell proliferation
regulation of mast cell degranulation
innate immune response
regulation of cell differentiation
positive regulation of myeloid cell differentiation
protein autophosphorylation
centrosome organization
regulation of cell motility
positive regulation of actin cytoskeleton reorganization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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