Proteintech

FGD5 Polyclonal Antibody

View all (8) FGD5 antibodies

Questions & Answers

Questions & Answers

Antibody Testing Data (5)

FGD5 Antibody in Immunocytochemistry (ICC/IF)

FGD5 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 5

FGD5 Antibody (20910-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells, using FGD5 antibody 20910-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

FGD5 Antibody in Immunocytochemistry (ICC/IF)

FGD5 Antibody in Immunocytochemistry (ICC/IF)

FGD5 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FGD5 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FGD5 Antibody in Western Blot (WB)

Product Image Gallery

FGD5 Antibody in Immunocytochemistry (ICC/IF) — Immunofluorescent analysis of HepG2 cells, using FGD5 antibody 20910-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

FGD5 Antibody in Immunocytochemistry (ICC/IF) — Immunofluorescent analysis of Hela cells, using FGD5 antibody 20910-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).

FGD5 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human lung using 20910-1-AP (FGD5 antibody) at dilution of 1:100 (under 40x lens).

FGD5 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human lung using 20910-1-AP (FGD5 antibody) at dilution of 1:100 (under 10x lens).

FGD5 Antibody in Western Blot (WB) — Mouse brain tissue were subjected to SDS PAGE followed by western blot with 20910-1-AP (FGD5 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

Product Details

20910-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

-

Immunocytochemistry (ICC/IF)

1:10-1:100

View 1 publication 1 publication

Immunoprecipitation (IP)

Assay-dependent

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

FGD5 Fusion Protein Ag15037 (923-1262 aa encoded by BC035364)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.17 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MRALDDMDH EGRDTLAREE LRQGLSELPA IHDLHQGILE ELEERLSNWE SQQKVADVFL AREQGFDHHA THILQFDRYL GLLSENCLHS PRLAAAVREF EQSVQGGSQT AKHRLLRVVQ RLFQYQVLLT DYLNNLCPDS AEYDNTQGAL SLISKVTDRA NDSMEQGENL QKLVHIEHSV RGQGDLLQPG REFLKEGTLM KVTGKNRRPR HLFLMNDVLL YTYPQKDGKY RLKNTLAVAN MKVSRPVMEK VPYALKIETS ESCLMLSASS CAERDEWYGC LSRALPEDYK AQALAAFHHS VEIRERLGVS LGERPPTLVP VTHVMMCMNC GCDFSLTLRR H (923-1262 aa encoded by BC035364)

Target Information

FGD5 activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. It mediates VEGF-induced CDC42 activation. It may regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation and may play a role in regulating the actin cytoskeleton and cell shape.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

VE-PTP inhibition stabilizes endothelial junctions by activating FGD5.

EMBO reports

Braun LJ,Zinnhardt M,Vockel M,Drexler HC,Peters K,Vestweber D

Mon Jul 01 00:00:00 UTC 2019

VE-PTP inhibition stabilizes endothelial junctions by activating FGD5.

EMBO reports

Braun LJ,Zinnhardt M,Vockel M,Drexler HC,Peters K,Vestweber D

Mon Jul 01 00:00:00 UTC 2019

VE-PTP inhibition stabilizes endothelial junctions by activating FGD5.

EMBO reports

Braun LJ,Zinnhardt M,Vockel M,Drexler HC,Peters K,Vestweber D

Mon Jul 01 00:00:00 UTC 2019

VE-PTP inhibition stabilizes endothelial junctions by activating FGD5.

EMBO reports

Braun LJ,Zinnhardt M,Vockel M,Drexler HC,Peters K,Vestweber D

Mon Jul 01 00:00:00 UTC 2019

VE-PTP inhibition stabilizes endothelial junctions by activating FGD5.

EMBO reports

Braun LJ,Zinnhardt M,Vockel M,Drexler HC,Peters K,Vestweber D

Mon Jul 01 00:00:00 UTC 2019

VE-PTP inhibition stabilizes endothelial junctions by activating FGD5.

EMBO reports

Braun LJ,Zinnhardt M,Vockel M,Drexler HC,Peters K,Vestweber D

Mon Jul 01 00:00:00 UTC 2019

FGD5 Regulates VEGF Receptor-2 Coupling to PI3 Kinase and Receptor Recycling.

Arteriosclerosis, thrombosis, and vascular biology

Farhan MA,Azad AK,Touret N,Murray AG

Fri Dec 01 00:00:00 UTC 2017

FGD5 Regulates VEGF Receptor-2 Coupling to PI3 Kinase and Receptor Recycling.

Arteriosclerosis, thrombosis, and vascular biology

Farhan MA,Azad AK,Touret N,Murray AG

Fri Dec 01 00:00:00 UTC 2017

FGD5 Regulates VEGF Receptor-2 Coupling to PI3 Kinase and Receptor Recycling.

Arteriosclerosis, thrombosis, and vascular biology

Farhan MA,Azad AK,Touret N,Murray AG

Fri Dec 01 00:00:00 UTC 2017

FGD5 Regulates VEGF Receptor-2 Coupling to PI3 Kinase and Receptor Recycling.

Arteriosclerosis, thrombosis, and vascular biology

Farhan MA,Azad AK,Touret N,Murray AG

Fri Dec 01 00:00:00 UTC 2017

Facio-genital dysplasia-5 regulates matrix adhesion and survival of human endothelial cells.

Arteriosclerosis, thrombosis, and vascular biology

Nakhaei-Nejad M,Haddad G,Zhang QX,Murray AG

Thu Nov 01 00:00:00 UTC 2012

Facio-genital dysplasia-5 regulates matrix adhesion and survival of human endothelial cells.

Arteriosclerosis, thrombosis, and vascular biology

Nakhaei-Nejad M,Haddad G,Zhang QX,Murray AG

Thu Nov 01 00:00:00 UTC 2012

Bioinformatics

Protein Aliases: FYVE, RhoGEF and PH domain-containing protein 5; Zinc finger FYVE domain-containing protein 23

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Gene Aliases: FGD5; ZFYVE23

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UniProt ID: (Human) Q6ZNL6

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Entrez Gene ID: (Human) 152273

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guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity protein binding small GTPase binding metal ion binding

cytoskeleton organization regulation of cell shape actin cytoskeleton organization regulation of Rho protein signal transduction regulation of GTPase activity positive regulation of GTPase activity filopodium assembly

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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