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Product Details
PA5-79250
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived human FGF1 recombinant protein (Position: F16-D155).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.05mg sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2746366
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - IHC: Human Mammary Cancer Tissue.
Target Information
FGF1 is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Acidic fibroblast growth factor; aFGF; beta-endothelial cell growth factor; ECGF; Endothelial cell growth factor; endothelial cell growth factor, alpha; endothelial cell growth factor, beta; FGF; FGF-1; Fibroblast growth factor; Fibroblast growth factor 1; fibroblast growth factor 1 (acidic); H-FGF-a; HBGF-1; Heparin-binding growth factor 1; M-FGF-a
Gene Aliases: AFGF; ECGF; ECGF-beta; ECGFA; ECGFB; FGF-1; FGF-alpha; FGF1; FGFA; GLIO703; HBGF-1; HBGF1
UniProt ID: (Human) P05230
Entrez Gene ID: (Human) 2246
protein tyrosine kinase activity
Ras guanyl-nucleotide exchange factor activity
fibroblast growth factor receptor binding
integrin binding
protein binding
growth factor activity
heparin binding
1-phosphatidylinositol-3-kinase activity
Hsp70 protein binding
S100 protein binding
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
MAPK cascade
activation of MAPK activity
angiogenesis
organ induction
signal transduction
multicellular organism development
cell proliferation
positive regulation of cell proliferation
fibroblast growth factor receptor signaling pathway
anatomical structure morphogenesis
positive regulation of endothelial cell migration
regulation of phosphatidylinositol 3-kinase signaling
peptidyl-tyrosine phosphorylation
cell differentiation
lung development
positive regulation of cell migration
activation of protein kinase B activity
cellular response to heat
phosphatidylinositol-3-phosphate biosynthetic process
positive regulation of MAP kinase activity
positive regulation of GTPase activity
positive regulation of cholesterol biosynthetic process
positive regulation of angiogenesis
positive regulation of transcription from RNA polymerase II promoter
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
positive regulation of epithelial cell proliferation
positive regulation of cell division
branch elongation involved in ureteric bud branching
positive regulation of ERK1 and ERK2 cascade
mesonephric epithelium development
regulation of endothelial tube morphogenesis
positive regulation of intracellular signal transduction
positive regulation of sprouting angiogenesis
regulation of endothelial cell chemotaxis to fibroblast growth factor
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