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Product Details
OSF00023W-150UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from aa region 180-230 of human FGF12 conjugated to an immunogenic carrier protein was used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 150 µL of sterile water. Centrifuge to remove any insoluble material.
The peptide is homologous in mouse and rat.
Specificity of this antibody: FGF12.
Target Information
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FGF; FGF-12; FHF-1; Fibroblast growth factor; Fibroblast growth factor 12; fibroblast growth factor 12B; fibroblast growth factor FGF-12b; Fibroblast growth factor homologous factor 1; fibroblast growth factor homologous factor 1b; Myocyte-activating factor
Gene Aliases: AV114868; B230343J05Rik; FGF-12; FGF12; FGF12B; FHF-1; FHF1; Fhf1b
UniProt ID: (Human) P61328, (Rat) P61150, (Mouse) P61329
Entrez Gene ID: (Human) 2257, (Rat) 170630, (Mouse) 14167
regulation of membrane depolarization
JNK cascade
chemical synaptic transmission
adult locomotory behavior
fibroblast growth factor receptor signaling pathway
positive regulation of sodium ion transport
neuromuscular process
regulation of sodium ion transmembrane transport
regulation of sodium ion transmembrane transporter activity
negative regulation of cation channel activity
signal transduction
cell-cell signaling
nervous system development
heart development
cardiac muscle cell action potential involved in contraction
regulation of neuronal action potential
regulation of voltage-gated sodium channel activity
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