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Invitrogen
FGF12 Polyclonal Antibody
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Product Details
PA5-27301
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human FGF12. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1.01 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2544777
Product Specific Information
Recommended positive controls: mouse brain.
Predicted reactivity: Mouse (100%), Rat (99%), Xenopus laevis (94%), Chicken (98%), Sheep (100%), Rhesus Monkey (99%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FGF; FGF-12; FHF-1; Fibroblast growth factor; Fibroblast growth factor 12; fibroblast growth factor 12B; fibroblast growth factor FGF-12b; Fibroblast growth factor homologous factor 1; Myocyte-activating factor
Gene Aliases: AV114868; B230343J05Rik; FGF-12; FGF12; FGF12B; FHF-1; FHF1
UniProt ID: (Human) P61328, (Mouse) P61329
Entrez Gene ID: (Human) 2257, (Mouse) 14167
regulation of membrane depolarization
signal transduction
cell-cell signaling
chemical synaptic transmission
nervous system development
heart development
adult locomotory behavior
fibroblast growth factor receptor signaling pathway
positive regulation of sodium ion transport
neuromuscular process
cardiac muscle cell action potential involved in contraction
regulation of neuronal action potential
regulation of sodium ion transmembrane transport
regulation of voltage-gated sodium channel activity
regulation of sodium ion transmembrane transporter activity
negative regulation of cation channel activity
JNK cascade
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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