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Invitrogen
FGF19 Polyclonal Antibody
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FGF19 Antibody (PA5-79253) in IHC (P)
Immunohistochemical analysis of Fgf19 (Fgf15) in a paraffin-embedded section of mouse colon tissue. Heat mediated antigen retrieval was performed in EDTA buffer (pH 8.0, epitope retrieval solution).The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 2 μg/mL rabbit anti-Fgf19 (Fgf15) antibody (Product # PA5-79253) overnight at 4°C. Peroxidase Conjugated Goat Anti-ra... View More
Product Details
PA5-79253
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived rat FGF19 recombinant protein (Position: R26-K218).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 4mg trehalose
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2746369
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - IHC: mouse colon tissue, rat colon tissue.
Target Information
FGF19, Fibroblast growth factor 19, is a protein that in humans is encoded by the FGF19 gene. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. The FGF19 gene is mapped to 11q13.3. The deduced 216-amino acid FGF19 protein contains asignal sequence and 2 cysteine residues that are conserved in the FGF family. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development. FGF19 stimulates hepatic protein and glycogen synthesis but does not induce lipogenesis. The effects of FGF19 are independent of the activity of either insulin or the protein kinase Akt and, instead, are mediated through a mitogen-activated protein kinase signaling pathway that activates components of the protein translation machinery and stimulates glycogen synthase activity. The orthologous protein in mouse is FGF15, which shares about 50% amino acid identity and has similar functions. Together they are often referred to as FGF15/19.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FGF; Fibroblast growth factor; fibroblast growth factor 15; fibroblast growth factor 19
Gene Aliases: Fgf15
Entrez Gene ID: (Rat) 170582
neural crest cell migration
positive regulation of protein phosphorylation
heart development
positive regulation of cell proliferation
fibroblast growth factor receptor signaling pathway
negative regulation of gene expression
positive regulation of glucose import
positive regulation of JNK cascade
positive regulation of ERK1 and ERK2 cascade
negative regulation of bile acid biosynthetic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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