Invitrogen

FGF2 Recombinant Rabbit Monoclonal Antibody (1N6K6)

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Datasheet
Protocols
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Datasheet
Protocols
Questions & Answers

Product Details

MA5-51426

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

1N6K6

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 100-200 of human FGF2 (NP_001997.5).
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3094197

Product Specific Information

Immunogen sequence: RAPERVGGRG RGRGTAAPRA APAARGSRPG PAGTMAAGSI TTLPALPEDG GSGAFPPGHF KDPKRLYCKN GGFFLRIHPD GRVDGVREKS DPHIKLQLQA E

Target Information

FGF2 (FGFb, fibroblast growth factor basic) belongs to the fibroblast growth factor (FGF) family, and interacts with high-affinity transmembrane receptors to influence cell proliferation and tissue neovascularization. FGF2 exists as five isoforms with distinct intracellular localizations and functions. The 18 kDa isoform is predominantly cytosolic and acts through cell surface receptors, whereas the 22, 22.5, 24 and 34 kDa isoforms are nuclear and may signal independent of transmembrane receptor pathways. In humans, the gene is located on the q arm of chromosome 4. FGF2 has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for FGF2 contains multiple polyadenylation sites, and is alternatively translated from non-AUG and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. Diseases associated with FGF2 dysfunction include Kaposi Sarcoma and corneal neovascularization.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Basic fibroblast growth factor; basic fibroblast growth factor bFGF; bFGF; FGF; fgf basic; FGF-2; FGF-b; Fibroblast growth factor; Fibroblast growth factor 2; fibroblast growth factor 2 (basic); H-FGF-b-147; H-FGF-b-154; HBGF-2; Heparin-binding growth factor 2; M-FGF-b; prostatropin

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Gene Aliases: BFGF; FGF-2; FGF2; FGFB; HBGF-2

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UniProt ID: (Human) P09038, (Mouse) P15655, (Rat) P13109

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Entrez Gene ID: (Human) 2247, (Mouse) 14173, (Rat) 54250

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Function(s)
protein tyrosine kinase activity Ras guanyl-nucleotide exchange factor activity fibroblast growth factor receptor binding cytokine activity protein binding growth factor activity heparin binding 1-phosphatidylinositol-3-kinase activity ligand-dependent nuclear receptor transcription coactivator activity chemoattractant activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity receptor binding
Process(es)
activation of MAPKK activity angiogenesis branching involved in ureteric bud morphogenesis organ induction positive regulation of protein phosphorylation positive regulation of endothelial cell proliferation cell migration involved in sprouting angiogenesis phosphatidylinositol biosynthetic process multicellular organism development positive regulation of cell proliferation negative regulation of cell proliferation fibroblast growth factor receptor signaling pathway embryo development ending in birth or egg hatching glial cell differentiation positive regulation of endothelial cell migration positive regulation of gene expression negative regulation of fibroblast migration positive regulation of phospholipase C activity growth factor dependent regulation of skeletal muscle satellite cell proliferation substantia nigra development positive regulation of cerebellar granule cell precursor proliferation cell differentiation hyaluronan catabolic process lung development inositol phosphate biosynthetic process wound healing positive regulation of cell fate specification positive regulation of MAP kinase activity positive regulation of blood vessel endothelial cell migration negative regulation of blood vessel endothelial cell migration positive regulation of phosphatidylinositol 3-kinase activity positive regulation of cell differentiation positive regulation of osteoblast differentiation positive regulation of angiogenesis positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of retinal cell programmed cell death positive regulation of smooth muscle cell proliferation response to axon injury stem cell development positive regulation of epithelial cell proliferation positive chemotaxis release of sequestered calcium ion into cytosol regulation of cell cycle positive regulation of cell division positive regulation of protein kinase B signaling cardiac muscle cell proliferation positive regulation of cardiac muscle cell proliferation corticotropin hormone secreting cell differentiation thyroid-stimulating hormone-secreting cell differentiation negative regulation of cell death chondroblast differentiation mammary gland epithelial cell differentiation angiogenesis involved in coronary vascular morphogenesis negative regulation of wound healing positive regulation of ERK1 and ERK2 cascade positive regulation of canonical Wnt signaling pathway positive regulation of sprouting angiogenesis regulation of endothelial cell chemotaxis to fibroblast growth factor positive regulation of endothelial cell chemotaxis to fibroblast growth factor aging MAPK cascade activation of MAPK activity chemotaxis signal transduction Ras protein signal transduction nervous system development organ morphogenesis regulation of phosphatidylinositol 3-kinase signaling peptidyl-tyrosine phosphorylation extracellular matrix organization somatic stem cell population maintenance phosphatidylinositol-3-phosphate biosynthetic process positive regulation of GTPase activity regulation of angiogenesis phosphatidylinositol phosphorylation phosphatidylinositol-mediated signaling embryonic morphogenesis
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