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NeoBiotechnologies
FGF21 (Fibroblast growth factor 21) Monoclonal Antibody (FGF21/4343)
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Product Details
26291-MSM3-P1
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
FGF21/4343
Immunogen
Recombinant fragment (around aa 91-209) of human FGF21 protein.
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
Protein A/G
Storage buffer
PBS with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Antibody is stable for 24 months.
Positive Control: Human kidney or breast cancer. Cellular Localization: Secreted (extracellular)
Specificity Comments: Fibroblast growth factor-1 (FGF-1), also designated acidic FGF, and fibroblast growth factor-2 (FGF-2), also designated basic FGF, are members of a family of growth factors that stimulate proliferation of cells of mesenchymal, epithelial and neuroectodermal origin. Additional members of the FGF family include the oncogenes FGF-3 (Int2) and FGF-4 (hst/Kaposi), FGF-5, FGF-6, FGF-7 (KGF), FGF-8 (AIGF), FGF-9 (GAF) and FGF-10-FGF-23. Members of the FGF family share 30-55% amino acid sequence identity and similar gene structure and are capable of transforming cultured cells when overexpressed in transfected cells. Cellular receptors for FGFs are members of a second multigene family including four tyrosine kinases, designated Flg (FGFR-1), Bek (FGFR-L), TKF and FGFR-3.
Target Information
The protein encoded by this gene is a member of the fibroblast growth factor family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this growth factor has not yet been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FGF; FGF-21; FGFL; Fibroblast growth factor; Fibroblast growth factor 21; PRO10196
Gene Aliases: FGF21; UNQ3115/PRO10196
UniProt ID: (Human) Q9NSA1
Entrez Gene ID: (Human) 26291
signal transduction
cell-cell signaling
positive regulation of cell proliferation
regulation of low-density lipoprotein particle clearance
response to activity
endoplasmic reticulum unfolded protein response
response to nutrient levels
cellular response to drug
positive regulation of low-density lipoprotein particle receptor biosynthetic process
positive regulation of glucose import
positive regulation of ERK1 and ERK2 cascade
cellular response to glucose stimulus
cellular response to low-density lipoprotein particle stimulus
endothelial cell apoptotic process
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
negative regulation of endothelial cell apoptotic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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