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Invitrogen
FGF8 Polyclonal Antibody
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FGF8 Antibody (PA5-47598) in IHC (P)
Immunohistochemical analysis of FGF8 in immersion fixed paraffin-embedded sections of human prostate. Samples were incubated in FGF8 polyclonal antibody (Product # PA5-47598) using a dilution of 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown) and counterstained with hematoxylin (blue). Specific staining was localized to epithelial and endothelial... View More
Product Details
PA5-47598
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived recombinant mouse FGF-8b Gln23-Arg215
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2608867
Product Specific Information
In direct ELISAs and Western blots, less than 1% cross-reactivity with recombinant human (rh) FGF acidic, rhFGF basic, rhFGF-4, rhFGF-5, rhFGF-6, rhFGF-7 and rhFGF-9 is observed. This antibody will cross-react with recombinant mouse FGF-8c in neutralizing bioassay.
Reconstitute at 0.2 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
Target Information
Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Plays a role in neurite outgrowth in hippocampal cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AIGF; androgen-induced; Androgen-induced growth factor; FGF; FGF-8; Fibroblast growth factor; Fibroblast growth factor 8; HBGF-8; Heparin-binding growth factor 8; MGC149376
Gene Aliases: Aigf; Fgf-8; Fgf8
UniProt ID: (Mouse) P37237
Entrez Gene ID: (Mouse) 14179
MAPK cascade
patterning of blood vessels
branching involved in ureteric bud morphogenesis
organ induction
kidney development
neural plate morphogenesis
heart looping
blood vessel remodeling
heart morphogenesis
outflow tract septum morphogenesis
outflow tract morphogenesis
epithelial to mesenchymal transition involved in endocardial cushion formation
apoptotic process
response to oxidative stress
multicellular organism development
determination of left/right symmetry
heart development
motor neuron axon guidance
mesodermal cell migration
positive regulation of cell proliferation
gonad development
fibroblast growth factor receptor signaling pathway
embryo development ending in birth or egg hatching
positive regulation of gene expression
telencephalon development
pallium development
subpallium development
forebrain dorsal/ventral pattern formation
cell proliferation in forebrain
forebrain neuron development
central nervous system neuron development
signal transduction involved in regulation of gene expression
cell differentiation
lung development
BMP signaling pathway
male genitalia development
thyroid gland development
otic vesicle formation
midbrain-hindbrain boundary development
dorsal/ventral axon guidance
embryonic heart tube development
limb morphogenesis
embryonic hindlimb morphogenesis
aorta morphogenesis
inner ear morphogenesis
regulation of odontogenesis of dentin-containing tooth
negative regulation of apoptotic process
negative regulation of neuron apoptotic process
cell fate commitment
positive regulation of mitotic nuclear division
positive regulation of organ growth
generation of neurons
forebrain morphogenesis
positive chemotaxis
positive regulation of cell division
negative regulation of cardiac muscle tissue development
pharyngeal system development
canonical Wnt signaling pathway
corticotropin hormone secreting cell differentiation
thyroid-stimulating hormone-secreting cell differentiation
bone development
lung morphogenesis
branching involved in salivary gland morphogenesis
neuroepithelial cell differentiation
dopaminergic neuron differentiation
cell migration involved in mesendoderm migration
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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